聚乙二醇稳定的单分散超小金纳米颗粒的制备与表征  

Preparation of PEG stabled monodisperse ultra-small gold nanoparticles

作　　者：霍帅东[1] 王东亮[1] 甘雅玲[1] 梁兴杰[1] 

机构地区：[1]国家纳米科学中心,中国科学院纳米生物效应与安全性重点实验室,北京100190

出　　处：《电子显微学报》2013年第5期378-382,共5页Journal of Chinese Electron Microscopy Society

基　　金：国家自然科学基金资助项目(No.81171455)

摘　　要：本实验采用制备金纳米颗粒的Schiffrin-Brust经典方法的思路,利用不同分子量的巯基化聚乙二醇作为稳定剂,硼氢化钠作为还原剂,在水相溶液中探索制备了超小尺寸金纳米颗粒。通过透射电镜观察和粒径统计分析可知制备得到的金纳米颗粒尺寸均一,单分散性良好。该制备方法简单,得到的超小金纳米颗粒稳定性良好,为生物医药领域的相关研究及应用提供了新的材料和模型。Ultra-small gold nanoparticles were obtained based on the classical Schiffrin-Brust method by using different molecular weight of polyethylene glycol amine as the stabilizer and sodium borohydride as the reducing agent reacted in an aqueous phase solution.The method of preparation is very simple.The gold nanoparticles obtained have a uniform morphology and good monodisperse stability in bio-media.This work provides a good prerequisite for research and applications of ultra-small gold nanoparticles in the field of biomedical.

关 键 词：超小尺寸 聚乙二醇 生物稳定 金纳米颗粒 

分 类 号：TB383.1[一般工业技术—材料科学与工程]