自身免疫性溶血性贫血患者血清可溶性人类白细胞抗原G水平测定及意义  

Detection of serum level of soluble human leukocyte antigen G in patients with warm autoimmune hemolytic anemia

作　　者：宋斌[1] 万楚成[1] 章正华[1] 李章志[1] 陈雁[1] 

机构地区：[1]湖北医药学院附属太和医院血液内科,湖北十堰442000

出　　处：《中华实用诊断与治疗杂志》2013年第11期1066-1067,共2页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的探讨血清可溶性人类白细胞抗原G(soluble human leukocyte antigen G,sHLA-G)在温抗体型自身免疫性溶血性贫血中的临床意义。方法 76例初治温抗体型自身免疫性溶血性贫血患者(WAIHA组),体检健康者48例(对照组),采用双抗体夹心ELISA法检测2组治疗前、后血清sHLA-G水平并进行比较。结果治疗前WAIHA组sHLA-G水平(13.57±5.19)μg/L高于对照组(6.15±4.11)μg/L(P<0.05);WAIHA组经治疗缓解者血清sHLA-G水平(6.20±3.89)μg/L低于治疗前及未缓解者(13.54±4.30)μg/L(P<0.05);未缓解者sHLA-G水平与治疗前比较差异无统计学意义(P>0.05)。结论 sHLA-G可能参与了温抗体型自身免疫性溶血性贫血的发病,检测sHLA-G水平对病情判断有重要价值。Objective To investigate clinical significance of soluble human leukocyte antigen G （sHLA G） in patients with warm autoimmune hemolytic anemia （WAIHA）. Methods Seventy-six patients with initial WAIHA （WAIHA group） and 48 healthy controls （control group） were detected serum levels of sHLA-G by ELISA before and after treatment. Results The serum level of sHLA G was significantly higher in WAIHA group before treatment than that in control group （P〈0.05）, and was lower in the patients with obvious response in WAIHA group after treatment than that before treatment and in the patients with no response after treatment in WAIHA group （P〈0.05）. There was no significant difference in sHLA G level after treatment in the patients with no response in comparison with before treatment （P〉0.05）. Conclusion sHLA-G is involved in the pathogenesis of warm autoimmune hemolytic anemia. The detection of sHLA-G level has an important value to the judgement of the severity of illness.

关 键 词：溶血性贫血 自身免疫性 可溶性人类白细胞抗原G 

分 类 号：R556[医药卫生—血液循环系统疾病]