炎症性肠病患者黏附分子-l、D-乳酸、二胺氧化酶的变化及临床意义  

Clinical significance of sICAM-1, plasma diamine oxidase and D-lactate in inflammatory bowel disease patients

作　　者：钟武装[1] 宋卫兵[1] 杨键[1] 肖丽萍[1] 杨明常[1] 刘岗[1] 谢涣琴[1] 蔡敏捷[1] 乐德[1] 

机构地区：[1]广州军区广州总医院干部病房二科,510100

出　　处：《现代消化及介入诊疗》2013年第5期273-276,共4页Modern Interventional Diagnosis and Treatment in Gastroenterology

基　　金：广东省自然科学基金博士启动项目(S2011040001277)

摘　　要：目的研究炎症性肠病(Inflammatory Bowel Disease,IBD)患者可溶性血清细胞间黏附分子-l(sICAM-1)、血浆D-乳酸、二胺氧化酶(DAO)、白细胞(WBC)的变化及其临床意义。方法将108例IBD患者和60例健康体检者分为观察组和对照组,对两组分别采用酶联免疫法测定血清sICAM-l,分光光度法检测D-乳酸和DAO水平,常规检查白细胞计数。结果 IBD患者sICAM-1、血浆D-乳酸、DAO、WBC明显高于对照组(P<0.01)。IBD患者sICAM-l与血浆D-乳酸、DAO、WBC水平均显著相关(P<0.01)。治疗前溃疡性结肠炎和克罗恩病两组患者间sICAM-l、DAO、D-乳酸、WBC的水平比较无显著差异性(P>0.05),而治疗后sICAM-l、DAO、D-乳酸水平显著低于治疗前(P<0.01)。结论 sICAM-1,血浆D-乳酸和DAO与病情程度密切相关,sICAM-1可作为IBD患者病情的主要监测指标之一。Objective To explore the change of sICAM-1, plasma diamine oxidase （DAO） and D-lac-tate in IBD patients and its clinical significance. Methods Sixty-eight patients with IBD were employed as experimental group, while 30 healthy people served as control group. The concentration of DAO and D-lactate was measured with spectrophotometric assay and sICAM-1 by ELISA assay. Results The concentration of sICAM-1, DAO and D-lactate in IBD group were significantly higher than those in control group （P〈0.01）. There were no significant differences among the levels of sICAM-1, DAO and D-lactate between ulcerative colitis and Crohn′s disease patients （P〉0.05）.The levels of sICAM-1, DAO and D-lactate in IBD patients were positively correlated with each other （P〈0.01）. After therapy, The levels of sICAM-1, DAO and D-lac-tate were decreased significantly in IBD patients （P〈0.01） after treatment. Conclusion The concentration changes of plasma sICAM-1, DAO and D-lactate in IBD patients are closely related to their clinical symp-toms, which could be a potential laboratory index for IBD patients.

关 键 词：炎症性肠病 细胞间黏附分子-l D-乳酸 二胺氧化酶 

分 类 号：R392.32[医药卫生—免疫学]