猪鼻支原体攻毒模型研究进展  

Advances in experimental study on Mycoplasma hyorhinis in animal models

作　　者：纪燕[1,2] 熊祺琰[1] 韦艳娜[1] 马庆红[1] 刘占军[1] 邵国青[1] 

机构地区：[1]江苏省农业科学院兽医研究所.农业部兽用生物制品工程技术重点实验室.国家兽用生物制品工程技术研究中心,南京210014 [2]南京农业大学动物医学院,南京210095

出　　处：《中国人兽共患病学报》2013年第11期1115-1118,1123,共5页Chinese Journal of Zoonoses

摘　　要：猪鼻支原体是第一种从猪体内分离到的病原体,可引起猪的肺炎、多发性浆膜炎、关节炎、中耳炎等临床症状,对养殖业造成巨大危害。同时证实其与多种人类肿瘤有明显的相关性,也是人类和多种动物细胞培养中常见的污染物。目前对猪鼻支原体的预防较为困难,暂无理想的抗生素和疫苗。猪鼻支原体攻毒模型是进行致病机理、疫苗评价及药物等研究的基础。本文就目前猪鼻支原体常用攻毒模型的研究进展进行综述。The Mycoplasma hyorhinis （Mhr）, the first pathogen isolated from pigs, can cause pneumonia, polyserosi- tis, arthritis, and otitis media, which causes great harm to aquaculture. To a certain extent, Mycoplasrna hyorhinis affected the growth and parturition performance of pigs. Recent studies have shown that the Mycoplasrna hyorhinis is significantly re- lated to a variety of human tumors, which also contaminates human and animal cell culture. However, the pathogenesis of My- coplasma hyorhinis in swine pneumonia and the mechanisms that Mycoplasma hyorhinis colonized in the respiratory tract and induced systemic disease are not well understood. Up to now, the prevention of Mycoplasma hyorhinis is＇very difficult, and it is still no ideal antibiotic or vaccine. Animal models are the foundation for pathogenesis studies, vaccine, and drug research on Mycoplasrna hyorhinis infection. The advances in experimental study on Mycoplasma hyorhinis in animal model are reviewed in this paper.

关 键 词：猪鼻支原体 攻毒模型 研究进展 

分 类 号：R375[医药卫生—病原生物学]