脱卤反应研究进展  

Research Progress on Dehalogenation Reaction

作　　者：薛福玲[1] 熊金锋[1] 莫广珍[1] 彭湃[1] 陈任宏[2] 汪朝阳[1] 

机构地区：[1]华南师范大学化学与环境学院 教育部环境理论化学重点实验室,广州510006 [2]广东食品药品职业学院,广州510520

出　　处：《有机化学》2013年第11期2291-2297,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20772035);广东省高等学校人才引进专项资金(No.粤财教[2011]431号);广东省自然科学基金(No.S2011010001556)资助项目~~

摘　　要：脱卤反应在环境保护、生物化学和有机合成等方面的重要应用,尤其是通过脱卤反应来实现C—H键的形成在有机合成中越来越受到化学家们的重视.根据反应底物的不同,综述了Csp3-X型、Csp2-X型底物近年来脱卤反应的研究情况,特别是芳基卤(含卤代芳杂环)、卤代烯酮、卤代内酯等不同结构的Csp2-X型底物脱卤形成C—H键反应的新进展,指出提高脱卤反应的选择性与实用性是其有机合成中进一步广泛应用的关键.同时,通过光化学反应脱卤的绿色化学新方法,也值得关注.Dehalogenation reaction has important applications in many fields, such as environmental protection, biochemistry and organic synthesis. Especially, more and more attention has been paid to the formation of C--H bond via the dehalogena- tion reaction in organic synthesis. Based on different reaction substrates, the recent research progresses on the dehalogenation reaction of Csp3-X and Csp2-X substrates, especially the aryl halides （including halogenated aromatic heterocycles）, halogen ketones, halogenated lactones, are reviewed. It is pointed that to improve the selectivity and practicality of dehalogenation reactions is the key for their further extensive uses in organic synthesis. At the same time, the dehalogenation via photochemi- cal reaction as a novel green chemistry route is also worthy of further study in the future.

关 键 词：脱卤反应 钯催化 还原反应 氢源 光化学反应 

分 类 号：O621.25[理学—有机化学]