钌络合物催化苯乙酮还原胺化反应的研究  

Reductive Amination Reaction of Acetophenone Catalyzed by Ruthenium Complex

作　　者：聂红芬 周宏勇[1] 李小娜[1] 李云庆[1] 王家喜[1] 

机构地区：[1]河北工业大学化工学院,天津300130

出　　处：《有机化学》2013年第11期2412-2416,共5页Chinese Journal of Organic Chemistry

基　　金：河北省自然科学基金(No.B2011202087)资助项目~~

摘　　要：α-胺基取代苯并咪唑衍生物L1～L4与RuCl2（PPh3）3原位组成催化体系，催化苯乙酮与甲酸铵的还原胺化反应形成α-苯乙胺、N-（1-苯乙基）甲酰胺及α-苯乙醇. 配体上大取代基及苯基取代基有利于提高催化剂的催化活性. 在85 ℃时苯乙酮的还原胺化反应较快，在125 ℃时，苯乙酮的氢转移形成苯乙醇成为主要的反应. 还原胺化反应的氢源及氨源为甲酸铵. 提出了反应的可能机理.The catalysts generated in situ from RuCl2（PPh3）3 and α-amino substituted benzimidazole derivatives L1～L4 were used to promote the reductive amination of acetophenone to generate α-phenylethylamine, N-（1-phenylethyl） formamide and α-phenylethanol. The bulkier substituent and phenyl group on the ligand will enhance the catalytic activity. The reductive amination of acetophenone was faster at 85 ℃, while the hydrogen transfer of acetophenone to α-phenylethanol became the main reaction at 125 ℃. The hydrogen and amine resouce is the ammonium formate. The plausible mechnism was proposed.

关 键 词：还原胺化 苯乙酮 甲酸铵 钌 

分 类 号：O621.25[理学—有机化学]