脉血康胶囊联合硫辛酸注射液治疗糖尿病周围神经病变的疗效观察  

Efficacy Observation of Maixuekang Capsules Combined with Lipoic Acid Injection on Diabetic Peripheral Neuropathy

作　　者：吕琳[1,2] 高卫真[1] 史宏岩[2] 

机构地区：[1]天津医科大学药理室,天津300070 [2]天津泰达国际心血管病医院,天津300457

出　　处：《中国药房》2013年第44期4170-4172,共3页China Pharmacy

摘　　要：目的:观察脉血康胶囊联合硫辛酸注射液治疗糖尿病周围神经病变(DPN)的临床疗效和安全性。方法:选择102例DPN患者,按随机数字表法均分为治疗组和对照组。所有患者均进行控制饮食、增加运动、口服降糖药物或注射胰岛素等常规治疗,待血糖达标后,治疗组患者给予脉血康胶囊3粒,tid+硫辛酸注射液0.3 g加入0.9%氯化钠注射液250 ml中静脉滴注,qd;对照组患者仅给予硫辛酸注射液0.3 g加入0.9%氯化钠注射液250 ml中静脉滴注,qd。两组患者疗程均为4周。比较两组患者的临床疗效,观察两组患者治疗前、后的神经传导速度及不良反应发生情况。结果:治疗后,治疗组患者的总有效率(90.2%)显著高于对照组(72.6%),两组比较差异有统计学意义(P<0.05);治疗后,两组患者的运动神经传导速度(MCV)、感觉神经传导速度(SCV)较同组治疗前均显著升高,且治疗组患者的MCV、SCV显著高于对照组,两组比较差异有统计学意义(P<0.05),两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论:脉血康胶囊联合硫辛酸注射液治疗DPN疗效较好,可促进神经纤维的修复,改善周围神经组织的微循环,且安全性较好。OBJECTIVE： To observe the clinical efficacy and safety of Maixuekang capsules combined with Lipoic acid injection on diabetic peripheral neuropathy （DPN）. METHODS： 102 DPN patients were randomly divided into treatment group and control group . The blood glucose of all patients was up to the standard after controlling diet, enhancing exercise and receiving routine insulin. Treatment group was given 3 pieces of Maixuekang capsules, tid, and Lipoic acid injection 0.3 g added into 0.9% Sodium chloride injection 250 ml, qd, ivgtt. Control group received Lipoic acid injection 0.3 g added into 0.9% Sodium chloride injection 250 ml, qd, ivgtt. Treatment course of 2 groups lasted for 4 weeks. Clinical efficacies of 2 groups were compared. The nerve conduction velocity and the occurrence of ADR were observed in 2 groups. RESULTS： Total effective rate of treatment group （90.2 % ） was significantly higher than control group （72.6%）; there was statistical significance （P〈0.05）. The motor nerve conduction velocity （MCV） and sensory nerve conduction velocity （SCV） of 2 groups were increased significantly after treatment, and those of treatment group was significantly higher than control group after treatment; there was statistical significance （P〈0.05）. There was no statistical significance in the incidence of ADR （P〉0.05）. CONCLUSIONS： Maixuekang capsules combined with Lipoic acid injection can promote nerve fiber recovery and microcirculation of peripheral nerve tissue and is effective in the treatment of DPN and show good safety.

关 键 词：脉血康 硫辛酸 糖尿病周围神经病变 疗效观察 

分 类 号：R587.1[医药卫生—内分泌]