烯氯化合物及其合成进展  

Advances in the Synthesis of Vinyl Chloride Compounds

作　　者：徐立宁[1] 张军涛[1] 陶成[1] 曹小平[1] 

机构地区：[1]兰州大学化学化工学院功能有机分子化学国家重点实验室,兰州730000

出　　处：《化学进展》2013年第11期1876-1887,共12页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21272098;21190034;21061160494;J1103307)资助

摘　　要：烯氯常见于天然产物中,并被认为是其生物活性官能团之一,在功能材料方面也多有应用,同时也是有机合成中一类重要的合成子。因而,烯氯的制备方法一直是有机合成化学和制药化学的热点研究内容之一。近年来,制备烯氯的新方法和新试剂不断出现,本文基于不同的反应类型,对烯氯的构筑方法进行了综述,并列举了海洋天然产物malyngamides全合成中烯氯应用的重要性。Vinyl chloride is an important functional group in many biologically and pharmaceutically active compounds, some vinyl chloride derivatives have been employed as organic materials, including polymers, and also are employed as the building block in organic synthesis. The construction of vinyl chloride is widely studied, new method and reagent are continuing to emerge in recently years. In this paper, the recent progress in the synthesis of vinyl chloride is reviewed according to the different reaction types, and its application in the total synthesis of marine natural product malyngamides is covered.

关 键 词：有机合成 烯氯 天然产物 malyngamides 

分 类 号：O621.3[理学—有机化学] O627[理学—化学]