低剂量非那雄胺维持治疗良性前列腺增生症中远期疗效观察  

Observation of long-term effects on maintained treatment of low dose of finasteride in treatment for benign prostatic hyperplasia

作　　者：陈焕清[1] 陈玉成[1] 符少萍[1] 缪瑞明[2] 李文平[3] 

机构地区：[1]中山大学孙逸仙纪念医院预防保健科,广州510120 [2]中山大学孙逸仙纪念医院超声科,广州510120 [3]中山大学孙逸仙纪念医院泌尿外科,广州510120

出　　处：《岭南现代临床外科》2013年第5期400-402,共3页Lingnan Modern Clinics in Surgery

基　　金：广东省科技计划项目基金(编号:2008B030301092)

摘　　要：目的探讨低剂量非那雄胺维持治疗良性前列腺增生症的中远期疗效。方法将105例经非那雄胺治疗显效的良性前列腺增生症病例随机分为3组,分别予以非那雄胺5 mg 1次/d、5 mg 1次/2 d及5 mg 1次/3d维持治疗3年,比较其各时点IPSS、Qmax、V、Ru和IIEF等指标的差异。结果非那雄胺5 mg 1次/3 d维持治疗组不能完成实验,非那雄胺5mg 1次/2 d维持治疗组除3年时点Qmax较低外,其余各时点指标与5 mg 1次/d维持治疗组比较无显著差异。结论非那雄胺5mg 1次/2 d维持治疗给药基本能维持良性前列腺增生症的中远期临床疗效。Objective To investigate the clinical efficacy of intermittent use of finasteride for benign prostatic hyperplasia （BPH）. Methods A total of 105 patients with BPH were divided into three groups according to administering the dose of finasteride, Group A （finasteride 5 mg l/d）, group B （5 mg/2 days） and group C （5 mg/3 days）. After 3 years of treatment, IPSS score, maximum flow rate, prostate volume,B-mode ultrasound measured residual urine volume and IIEF-5 were measured and analyzed. Results Group C was canceled ahead of schedule for high incidence of exacerbation. After treatment, there were no statistically significant differences between group A and group B in terms of IPSS score, prostate volume, B-mode ultrasound measured residual urine volume and IIEF-5 （P〉0.05）. Compared with group A, the maxium flow rate significantly decreased in group B after 3 years treatment （P〈0.05）. Conclusion The usage of 5 mg/2 days of finasteride may be as effective as daily administration for the treatment of BPH.

关 键 词：低剂量 非那雄胺 性前列腺增生症 疗效 

分 类 号：R697.3[医药卫生—泌尿科学]