Notch信号通路在肿瘤中的研究进展  

Advances in research of Notch signaling pathway in cancer

作　　者：李钰泉[1] 周天骏[1] 潘越江[1] 张惠忠[1] 

机构地区：[1]中山大学孙逸仙纪念医院胸外科,广州510120

出　　处：《岭南现代临床外科》2013年第5期455-458,共4页Lingnan Modern Clinics in Surgery

基　　金：广东省自然科学基金(编号:S2011010006056)

摘　　要：Notch信号通路是一条影响细胞命运、保守而重要的信号转导通路,几乎涉及所有细胞的生长活动,在调节细胞分化、增殖和凋亡,及在一系列生理、病理过程中都起着关键性的作用,并在肿瘤的发生、发展中也发挥了至关重要的作用。近年对Notch信号通路的研究不断加深和完善,使其与肿瘤的密切关系得到了充分呈现,并有望针对相关靶点设计靶向药物,为肿瘤治疗提供新方向。Notch signaling pathway is an important and conservative signal transduction pathway which determines cell fate and is involved in almost all activities of proliferation and differentiation of cell. It plays a significant role in the regulation of cell proliferation, apoptosis, differentiation, as well as a series of physio｜ogical and pathological processes. In addition, it has a vital effect in cancer occurrence and development. As the studies becoming further and further, it proves that cancer has much to do with the Notch signaling pathway, which may make new drugs for the targeted therapy come into being. All of this can offer a new direction for the treatment of cancer.

关 键 词：NOTCH信号通路 肿瘤 靶向治疗 

分 类 号：R602[医药卫生—外科学]