免疫微生态营养替代传统肠道准备在结直肠癌中的应用  

Application of immune micro-ecological nutrition in preoperative bowel preparation for patients with colorectal carcinoma

作　　者：刘战丛[1,2] 王丽萍[1,2] 李贺鹏[1,2] 

机构地区：[1]漯河医学高等专科学校第二附属医院 [2]漯河市第五人民医院普外科,河南漯河462300

出　　处：《中国现代医生》2013年第31期18-19,22,共3页China Modern Doctor

摘　　要：目的观察免疫微生态营养作为肠道准备方法的有效性及患者术后炎症反应及免疫状态。方法将62例行择期结直肠癌根治性手术的患者随机分为试验组31例和对照组31例。对照组采用传统的3 d肠道准备方法;试验组在术前3 d给予患者免疫微生态营养。术前及术后第1次排便检测粪便中肠道菌群,术中观察肠道清洁度,检测术前及术后第4天免疫球蛋白IgG、IgA、IgM,血清补体C3、C4及血清C反应蛋白浓度;观察术后排气时间,感染发生例数等情况。结果试验组和对照组清肠效果的优良率无显著性差异。术后第4天,免疫球蛋白、血清补体试验组明显高于对照组。血清C反应蛋白浓度术后试验组明显低于对照组。术后患者排气时间较对照组明显提前,感染发生例数试验组少于对照组(P<0.05),两组有统计学差异。结论免疫微生态营养作为肠道准备方法有效可行。益于术后重建肠道菌群,且有利于结直肠癌术后肠道功能的保护及恢复,减少术后早期炎性反应,改善患者免疫功能。Objective To observe the effect of immune micro-ecological nutrition as bowel preparation method on postoperative inflammatory reaction and immune condition in patients with colorectal cancer. Methods Sixty two pa- tients with colorectal cancer were randomly divided into either trial group or control group. Three-day conventional bowel preparation was administered in the control group, while immune micro-ecological nutrition was administered in the trial group. Quality of the preparation was estimated during operation. Intestinal flora in the stool, immune globu- lins,and serum C-reactive protein were measured before and 4 d after the operation, Meanwhile,the time required for intestinal function recovery and incidence of postoperative complications were recorded. Results Good and excellent bowel preparation was achieved in two groups. There was no significant difference between them.Postoperative immune globulins serum C3 and C4 were significantly higher in the trial group than in the control group,while postoperative serum C-reactive protein was significantly lower in the trail group than in the control group. The time required for in- testinal function recovery was significantly shorter in the trial group than in the control group. There are statistical dif- ference between the two groups. Concusion Immune micro-ecological nutrition as bowel preparation method is effec- tive and feasible in reconstructing postoperative intestinal flora, recovering postoperative intestinal function, diminish- ing early postoperative inflammatory reaction and building up patients immune function.

关 键 词：结直肠肿瘤 肠道准备 免疫微生态营养 

分 类 号：R453.9[医药卫生—治疗学]