女性泌尿生殖道支原体属感染及药敏分析  

Mycoplasma infections in the female genitourinary tract and drug susceptibilities of the Mycoplasmas

作　　者：张正国[1,2] 贺庆伟[1] 杨玉林[1] 

机构地区：[1]河南省中医院检验科,河南郑州450002 [2]郑州大学基础医学院

出　　处：《现代预防医学》2013年第22期4153-4154,4158,共3页Modern Preventive Medicine

摘　　要：目的了解女性泌尿生殖道支原体属感染状况及对抗菌药物的药敏情况。方法采用支原体培养药敏试验试剂盒,对1 126例泌尿生殖道标本进行支原体培养及10种抗生素的体外药物敏感试验。结果在1 126例受检病例中支原体阳性512例,总阳性率为45.47%(512/1 126);其中解脲脲支原体阳性419例,占阳性病例的81.84%(419/512);人型支原体阳性15例,占2.93%(15/512);解脲脲支原体和人型支原体阳性78例,占15.23%(78/512)。药敏试验结果表明解脲脲支原体阳性者其对抗生素的敏感性从高到低依次为交沙霉素、克拉霉素、米诺环素、多西环素,而耐药率从高到低依次为:大观霉素、阿奇霉素、罗红霉素、环丙沙星、氧氟沙星、司帕沙星。解脲脲和人型支原体混合感染者耐药率明显高于单纯解脲脲支原体感染者,其中大观霉素、阿奇霉素、罗红霉素、环丙沙星、氧氟沙星五种药物的耐药率在70%以上。结论临床上疑似支原体感染的患者要进行支原体的培养及药敏试验,并根据支原体感染状况及药敏情况对临床治疗女性泌尿生殖道支原体感染有重要的指导价值。OBJECTIVE The study aimed to assess the prevelance of Mycoplasma infections in the female genitourinary tract and the drug susceptibility of the Mycoplasmas against antibacterial drugs. METHODS A Mycoplasma examination kit was used to culture Mycoplasmas in 122 genitourinary tract specimens and to assess the in vitro drug susceptibility of the My- coplasmas against 10 antibiotics. RESULTS 512 of the 1126 examined cases were tested Mycoplasma-positive, resulting in an overall positive rate of 45.47% （512/1126）. Among the 512 Mycoplasma-positive cases, 419 cases were Ureaplasma ure- alyticum-positive （81.48%）, 15 cases were Mycoplasma hominis-positive （2.93%）, and 78 cases were Ureaplasma ure- alyticum- and Mycoplasma hominis-positive （15.23%）. Drug susceptibility results indicated that the Ureaplasma urealyticum- positive patients had the highest to lowest susceptibility against josamycin, clarithromycin, minoeycline, and doxycycline and exhibited the highest to lowest resistance rate against spectinomycin, azithromycin, roxithromycin, ciprofloxacin, ofloxacin, and sparfloxacin. Drug resistance rate in patients with mixed infections of Ureaplasma urealyticum and Mycoplasma hominis was significantly higher than that in patients infected with Ureaplasma urea!yticum alone; drug resistance rate against specti- nomycin, azithromycin, roxithromycin, ciprofloxacin, and ofloxacin in the doubly infected patients were higher than 70%. CONCLUSION Suspected cases of Mycoplasma infections should be examined by Mycoplasma culture and drug susceptibility test. Identification of the strains for Mycoplasma infections and drug susceptibility of the strains provide important guidelines for the treatment of Mycoplasma infections in the female genitourinary tract.

关 键 词：泌尿生殖道 支原体 抗生素 耐药性 

分 类 号：R691.3[医药卫生—泌尿科学]