非HIV感染的获得性免疫缺陷  

HIV negative acquired immune deficiency

作　　者：孔晓飞[1,2] 

机构地区：[1]美国洛克菲勒大学人类感染病与遗传学实验室 [2]上海交通大学医学院附属瑞金医院

出　　处：《中华实验和临床感染病杂志（电子版）》2013年第4期1-3,共3页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：上海市科委晨光计划;上海市卫生局青年公共卫生人才计划;国家自然科学基金(No.30800612)

摘　　要：临床中由不同的细菌,真菌和病毒感染所致的感染性疾病的患者免疫缺陷包括原发性或获得性免疫缺陷两大类,前者因遗传基因缺陷引起,后者因HIV感染所致。新的获得性免疫缺陷逐渐浮出水面,其发病机制特殊,本文介绍该方面的临床感染和免疫学研究的进展,着重强调强中和力抗-IFN-γ所致的分枝杆菌易感综合征,另名为成人起病型免疫缺陷;同时介绍其他中和性抗细胞因子抗体所致的获得性免疫缺陷及其相关感染。这一领域的快速发展,会发现更多与传染性疾病有关的致病性抗体。Patients with either primary or acquired immune deficiency presented with clinical susceptibilities to infectious diseases caused by different bacteria, fungi and viruses. The major difference between primary and acquired deficiency was based on the etiologies, due to either genetic defects or HIV infection. A new subset of acquired immune deficiency was defined recently due to the occurrence of neutralizing antibodies against cytokines. Patients with neutralizing antibodies against IFN-γ showed severe opportunistic intracellular bacterial infection, which was similar to the clinical phenotypes of patients with mendelian susceptibility to Mycobacterial disease （MSMD）. More neutralizing antibodies against other cytokines were also reported to confer susceptibilities to different pathogens, including staphylococcus, Candida albican, Cryptococcus neoformans and so on. This ifeld is evolving quickly with more pathogenic antibodies to be associated with infectious diseases.

关 键 词：获得性免疫缺陷 非HIV感染 抗细胞因子抗体 遗传基因缺陷 临床感染 感染性疾病 IFN-Γ 传染性疾病 

分 类 号：R392[医药卫生—免疫学]