匹伐他汀与阿托伐他汀治疗高脂血症的比较  

Comparison of curative effects of pitavastatin and atorvastatin in hypercholestrolemia

作　　者：侯海霞[1] 华琦[1] 刘荣坤[1] 杨峥[1] 

机构地区：[1]首都医科大学宣武医院心脏科,北京100053

出　　处：《中华保健医学杂志》2013年第5期388-390,共3页Chinese Journal of Health Care and Medicine

基　　金：首都医学发展基金(2009-1054)

摘　　要：目的比较匹伐他汀(2 mg)与阿托伐他汀(10 mg)治疗高脂血症的有效性和安全性。方法采用随机、阳性对照、单盲的研究方法。将经过4周饮食控制及安慰剂洗脱的高脂血症患者68例随机分为阿托伐他汀组(35例)与匹伐他汀组(33例),治疗8周后,观察其血脂水平变化。结果治疗8周后与治疗前相比,两组总胆固醇、低密度脂蛋白胆固醇、三酰甘油水平均降低,高密度脂蛋白胆固醇均升高,治疗前后血脂变化幅度差异均无统计学意义(P>0.05)。两组间不良反应发生率比较,差异无统计学意义(P>0.05)。结论匹伐他汀在疗效和安全性上不劣于阿托伐他汀。Objective To compare the efficacy and safety between pitavastatin and atorvastatin in treatment of hyperlipimia. Methods A randomized,positive-control,and single-blind clinical trial was lasted eight weeks,sixty-eight patients with hypercholesterolemia were randomly divided into two groups：atorvastatin 10 mg/d in 35 cases and pitavastatin 2 mg/d in 33 cases respectively. Results The levels of TC,TG,LDL-C decreased while HDL-C increased in both groups. There were no significant differences in the reduction of LDL-C,TC,TG and elevation of HDL-C between two groups （P〉0.05）. Conclusions The safety and efficacy of atorvastatin and pitavastatin are equal.

关 键 词：匹伐他汀 阿托伐他汀 高脂血症 

分 类 号：R589.2[医药卫生—内分泌]