支配子宫的植物神经和肥大细胞与子宫免疫调节的关系  

Relationship Between Autonomic Nerves Controlling Uterus and Regulation of Uterine Immunity

作　　者：袁学军[1] 乔惠理[2] 

机构地区：[1]黑龙江八一农垦大学动物科技学院,密山158308 [2]中国农业大学生物学院,北京100094

出　　处：《动物医学进展》2000年第3期25-27,共3页Progress In Veterinary Medicine

基　　金：国家自然基金资助项目! ( 3 950 0 1 0 8)

摘　　要：本文概述了近年来子宫的植物性神经支配、子宫肥大细胞 ( MC)的最新研究概况 ,阐述了植物性神经通过子宫肥大细胞对子宫免疫的影响及 P物质对子宫免疫的调节。植物性神经可通过抑制子宫 MC的增殖和组织胺释放来抑制子宫局部免疫水平。神经肽 P物质能刺激子宫 MC组织胺和细胞因子的释放来调节子宫免疫 ,但组织胺的释放与子宫的生殖状态有关。神经肽对 MC功能的调节是免疫—神经—内分泌网络相互作用的一个侧面 ,深入研究神经肽对 MC作用的机理 。In the article,we introduced the advance on study of uterine mast cells (MCs) and autonomic innervation of uterus in recent years,expounded effect of autonomic nerves on uterine immunity by uterine MCs and regulation of substance P on uterine immunity.Autonomic nerves may restrain proliferation of uterine MCs and releasing of histamine from uterine MCs to decrease the level of local cellular immune in uterus MCs to modualte uterine immunity,however,the release of histamine depend on the phase of reproductive cycle.Modulation for MCs by neuro peptides is a side of interaction in immune neuroendoctine communication.The profound research for mechanism of effect of neuro peptides on MCs will promote the development of Neuroimmunity.

关 键 词：植物性神经 肥大细胞 子宫免疫 

分 类 号：Q492.5[生物学—生理学] Q425