中国人血管紧张素转换酶基因插入/缺失多态性与阿尔茨海默病关系的Meta分析  

A META-ANALYSIS OF RELATIONSHIP BETWEEN ANGIOTENSION-CONVERTING EN-ZYME INSERTION/DELETION(I/D)POLYMORPHISM AND ALZHEIMER DISEASE AMONG THE CHINESE POPULATION

作　　者：谢德祥[1] 蒙莲[2] 唐玉兰[2] 

机构地区：[1]广西医科大学,南宁530021 [2]广西医科大学第一附属医院神经内科

出　　处：《广西医科大学学报》2013年第5期701-704,共4页Journal of Guangxi Medical University

基　　金：广西自然科学基金资助项目(No.2012jjAA40031)

摘　　要：目的:评价血管紧张素转换酶(angiotension-converting enzyme,ACE)基因I/D多态性与中国人阿尔茨海默病(Alzheimer disease,AD)的关系。方法:检索Medline、Cochrane图书馆、中国生物医学文献数据库、中国知网、万方和维普等数据库,按照纳入及排除标准纳入关于中国人ACE基因I/D多态性与AD的病例对照研究,采用Recman5.1软件进行Meta分析。结果:最终纳入7篇文献,Meta分析的结果显示,总体分析未发现ACE基因I/D多态性与AD相关,亚组分析显示,在内地汉族人,携带I等位基因及II基因型的人群患AD的风险更高,合并的OR值分别为1.66[95%CI(1.31,2.12),2.17[95%CI(1.54,3.05)]。结论:ACE基因I/D多态性与内地汉族人AD的发病易感性相关。Objective： This review was aimed to evaluate the relationship between angiotension-converting enzyme （ACE） gene polymorphism and susceptibility to Alzheimer disease （AD） among the Chinese popu- lation. Methods： We searched MEDLINE, Coehrane library, CBM, CNKI, WANFANG, VIP and other e- lectronic database for case-control studies that discuss the relationship between ACE gene insertion （I）/de- letion （D） polymorphism and AD in Chinese population. Meta-analyses were conducted using Revman 5.1 software. Results： We finally included 7 studies. The results of recta-analysis did not find that the ACE gene I/D polymorphism increased risk of AD in general population. The analysis of the subgroup showed that, Han Chinese population in the mainland, carrying the I allele and II genotype had higher risk of AD, the pooled OR values of AD with I allele and II genotype were 1. 66[95%CI（1.31, 2.12） and 2.17[95%CI （1.54, 3.05）. Conclusion： ACE gene I/D polymorphism is associated with the susceptibility to AD in the mainland Han population.

关 键 词：阿尔茨海默病 血管紧张素转换酶 痴呆 基因多态性 META分析 

分 类 号：R33[医药卫生—人体生理学]