当归植物化学和药理学研究进展(英文)  

Phytochemical and pharmacological studies on Radix Angelica sinensis

作　　者：陈晓鹏[1,2,3] 李伟[3] 肖学凤[4] 张兰兰[3] 刘昌孝[2] 

机构地区：[1]天津大学化工学院,天津300072 [2]天津药物研究院释药技术与药代动力学国家重点实验室,天津300193 [3]天津天士力制药集团股份有限公司,天津300410 [4]天津中医药大学,天津300193

出　　处：《中国天然药物》2013年第6期577-587,共11页

基　　金：supported by the National Key Subject of Drug Innovation(No.2013ZX09402-202)~~

摘　　要：当归是传统中药方剂中一味常用的草药,可以补血、治疗痛经和其他妇科疾病。作为保健食品和食品添加剂,当归也在亚洲和欧美地区销售。它的补血、抗氧化和免疫调节作用已经广为人知。近期研究表明,当归在抗肿瘤、改善记忆力、抗辐射和神经保护方面也有一定作用。植物化学研究从当归中分离得到了有机酸、苯酞和多糖等多类物质。根据最近的动物研究和临床实验,当归可以用于治疗妇科疾病、心脑血管疾病、神经系统疾病和肾病综合症。综述了近年来有关当归植物化学、药理学、药物相互作用、临床应用和毒性方面的研究进展,以使其药用价值得到进一步的认识,并使其应用前景更广阔。The roots of Angelica sinensis （RAS）, are a Chinese herbal medicine traditionally used in prescriptions for replenishing blood, treating abnormal menstruation, and other women＇s diseases. It has also been widely marketed as health food for women＇s care in Asia, and as a dietary supplement in Europe and America. RAS is well-known for its hematopoietic, antioxidant, and immunoregu- latory activities. RAS also possesses anti-cancer, memory, radioprotective, and neuroprotective effects. Phytochemical investigations on this plant led to organic acids, phthalides, polysaccharides, and other metabiolites. Based on recent animal studies and clinical trials, RAS has been used in the treatment of gynecologic diseases, cardio-cerebrovascular disease, nervous system diseases, and nephrotic syndrome. In this review, the recent phytochemical and pharmacological studies, drug-drug interactions, clinical applications, and toxicity of RAS are summarized.

关 键 词：当归 植物化学 药理学 药物相互作用 临床应用 毒性 

分 类 号：R284[医药卫生—中药学] R965[医药卫生—中医学]