天然药物中的单体对脑缺血保护作用的实验研究进展(英文)  

Progress on the protective effect of compounds from natural medicines on cerebral ischemia

作　　者：尚远宏[1,2] 田金凤[2] 侯敏[1] 徐晓玉[1] 

机构地区：[1]西南大学药学院重庆市药效评价工程技术研究中心,重庆400716 [2]攀枝花学院医学院,攀枝花617000

出　　处：《中国天然药物》2013年第6期588-595,共8页

基　　金：supported by the Science and Technology Research Project of Chongqing(No.CSTC2010AC5011);Ministry of Education Doctoral Program special fund(No.20110182110012);the Key Projects of Chinese Medicine Research of Chongqing Municipal Health Bureau(2010[60]2010-1-4)~~

摘　　要：天然药物治疗缺血性脑血管病历史悠久,积累了丰富的理论知识和治疗经验。综述近10年来天然药物中的单体成分,经复杂的病理生理机制,对脑缺血保护作用的实验研究,并选择其中代表性的16个单体按其病理生理机制分别介绍。天然药物保护缺血性脑损伤具有复杂的病理生理机制,主要通过降低兴奋性神经递质(银杏内酯B),抑制细胞凋亡(灯盏花素),影响星形胶质细胞活化和增殖(丹参酮ⅡA)及自由基(人参皂苷Rd),保护血脑屏障(黄芩苷)和减轻炎症反应(川芎嗪)等途径来实现,具有多靶点、多层次、多环节的脑保护作用。因此,研究天然药物单体通过脑缺血的病理生理机制中的各种途径来实现对缺血性脑损伤的保护作用,将有助于更好地治疗脑缺血患者和开发缺血性脑损伤保护作用的新制剂。The treatment of cerebral ischemic disease by natural medicines has a long history, and has accumulated a rich theo- retical knowledge and treatment experience. The objective of this review is to critically evaluate the experimental research situation of the protective effect of the individual compounds from natural medicine on cerebral ischemia in the past ten years, emphasizing the major mechanisms underlying cerebral ischemic pathophysiology. Sixteen representative compounds from natural medicines which are often used to treat stroke are discussed. The results indicate that these components possess a protective effect on cerebral ischemia, and that these components have different mechanisms, including inhibiting excitotoxicity by ginkgolide B, antiapoptosis of breviscapine, influencing astrocytic activation and proliferation of tanshinone IIA, influencing free radicals by ginsenoside Rd, impairing blood-brain barrier disruption by baicalin, and the anti-inflammatory activity of tetramethylpyrazine. Moreover, some components have multiple neuroprotective mechanisms. Therefore, the combination of individual compounds from natural medicines, considering the mecha- nisms of cerebral ischemia, may be beneficial to patients with cerebral ischemia in the future. This approach will provide a direction for

关 键 词：天然药物 单体 脑缺血 病理生理机制 研究进展 

分 类 号：R965[医药卫生—药理学]