山楂叶总黄酮缓释胶囊稳定性研究  

Stability of Sustained-release Capsules of Flavonoids from Hawthorn Leaves

作　　者：黄竹珺[1,2,3] 胡程[1] 周英[1,2] 王慧娟[1,2] 

机构地区：[1]贵州大学生命科学学院,贵州贵阳550025 [2]普洱学院生命科学系,云南普洱665000 [3]贵州大学贵州省中药(民族药)创制工程中心,贵州贵阳550025

出　　处：《山地农业生物学报》2013年第5期437-441,共5页Journal of Mountain Agriculture and Biology

基　　金：贵州省中药现代化科技产业研发专项"山楂叶总黄酮缓释制剂的研制与开发"[黔科合社字(2008)5024号];贵州大学研究生创新基金"山楂叶总黄酮缓释胶囊的研制"(农科2012017);教育部新世纪优秀支持计划[教技函(2011)95号];贵州省优秀青年科技人才培养对象专项资金项目[黔科合人字2011(34)号];贵州省高校工程技术研究中心建设项目"中药民族药创制工程中心建设"[黔教合KY字(2012)018号]

摘　　要：采用HPLC法,测定缓释胶囊中金丝桃苷与牡荆素鼠李糖苷的含量,释放度试验采用UV-Vis法测定溶出介质中总黄酮的含量。结果表明:高温和高湿条件下,放置10 d后胶囊体外释放度无明显变化,但胶囊壳变软,微丸有结块现象,且金丝桃苷与牡荆素鼠李糖苷含量均有明显下降;强光照射条件下,胶囊外观及释放度均无明显变化,但金丝桃苷与牡荆素鼠李糖苷含量均有明显下降。因此,建议选用避光、防潮包装材料,置干燥阴凉处保存。The content of Hyperoside and Rhamnosylvitexin in the capsules was determined by HPLC method.The content of flavonoids in dissolving medium was detected by UV-Vis method in the release test.The results showed that there were no significant differences in the release characteristics of capsules in vitro under the condition of high temperature and high humidity after 10 days,but the capsule shells softened,pellets began to agglomerate and the content of Hyperoside and Rhamnosylvitexin decreased significantly.In the strong light test the appearance and the release characteristics of the capsules had no obvious change,but the content of Hyperoside and Rhamnosylvitexin decreased significantly.Consequently,the sustained-release capsules should be kept in moisture-proof,light-resistant packaging materials and stored in a dry and cool place.

关 键 词：山楂叶总黄酮 缓释胶囊 金丝桃苷 牡荆素鼠李糖苷 释放度 

分 类 号：Q946[生物学—植物学]