348株社区皮肤及软组织感染病原菌分布及耐药性分析  

Study on distribution and resistance of 348 bacterial isolates from community-associated skin and soft tissue infection

作　　者：孟灵[1] 王应芳[1] 朱金芬[1] 郜莉娜[1] 魏玉平[2] 

机构地区：[1]兰州大学第二医院检验中心,兰州730030 [2]兰州大学第二医院皮肤科,兰州730030

出　　处：《检验医学与临床》2013年第21期2803-2804,2806,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨本地区社区皮肤及软组织感染(SSTIs)病原菌分布及其耐药性,为临床合理用药提供科学依据。方法对该院2009年1月至2012年12月符合社区SSTIs诊断标准的患者留取分泌物或脓液等标本进行细菌培养、病原菌鉴定及药物敏感试验,使用WHONET5.5软件进行分析。结果革兰阳性球菌占85.3%,金黄色葡萄球菌占54.6%,耐甲氧西林金黄色葡萄球菌(MRSA)检出率3.1%。甲氧西林敏感金黄色葡萄球菌(MSSA)、MRSA对青霉素、氨苄青霉素、红霉素耐药率分别高于90%、90%、70%,未检出对万古霉素、替考拉宁、利奈唑胺耐药的葡萄球菌。结论金黄色葡萄球菌是本地区社区SSTIs最常见的病原菌,临床应做到有样必采以确定病原菌,合理使用抗菌药物以减缓耐药菌产生。Objective To investigate the distribution of pathogens caused skin and soft-tissue infection and de- termine the major pathogens susceptibility to antimicrobial agents in the community. Methods The pus or wound se- cretion of out-patients with skin and soft tissue infection were collected. Bacterial culture and identification were per- formed. The major pathogens susceptibility to antimicrobial agents was tested. Results Of 348 pathogens,gram posi- tive coccus accounted for 85.3% and S. aureus accounted for 54. 6%. The prevalence of MRSA in S. aureus was 3.1%. The resistance rate of Staphylococcus spp. to penicillin, ampicillin and erythromycin were more than 90%, 90%,and 70%,respectively. No staphylococcus isolates was found resistant to vancomycin, teicoplanin or linezolid. Conclusion S. aureus was the major pathogenic bacterium for skin and soft tissue infection in the community of Lanzhou. The low prevalence of CR--MRSA was observed. Penicillin,ampicillin and erythromycin should not be the first choice for practical treating skin and soft--tissue infections. Rational drug use scheme is called in clinical prac- tice to prevent development of high level resistance.

关 键 词：皮肤及软组织感染 病原菌 耐药性 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]