胱氨酸蛋白酶抑制剂C对早期糖尿病肾病的诊断价值  

Diagnostic value of cystine protease inhibitor C in early diabetic nephropathy

作　　者：何健[1] 严海燕[1] 庄豪[1] 罗晓红[1] 

机构地区：[1]中山大学孙逸仙纪念医院检验科,广州510120

出　　处：《检验医学与临床》2013年第21期2820-2821,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨血清胱氨酸蛋白酶抑制剂C(CysC)对糖尿病肾病的诊断价值。方法用IMMULITE2000分析仪(化学发光酶免疫法)检测糖尿病肾病患者(251例,病例筛选自中山大学孙逸仙纪念医院病案库,2006年1月至2012年12月)的尿清蛋白,并依尿清蛋白排泄率(UAER)检测结果分为正常蛋白尿组(UAER<20μg/min,96例)、微量蛋白尿组(20μg/min≤UAER<200μg/min,82例)、临床蛋白尿组(UAER≥200μg/min,73例),以健康体检者为健康对照组(100例)。用日立7170型全自动生化分析仪检测各组受试对象血清CysC、尿素(BUN)、肌酐(Crea)水平,比较各组间上述血清学检测指标(多因素方差分析),进而评估各参数对早期糖尿病肾病的诊断价值。结果正常蛋白尿组的CysC值与健康对照组相比,差异无统计学意义(P>0.05),微量蛋白尿组和临床蛋白尿组的CysC值与健康对照组相比,差异均有统计学意义(P<0.05);临床蛋白尿组与健康对照组的BUN和Crea值相比,差异均有统计学意义(P<0.05),但其他组与健康对照组相比,差异均无统计学意义(P>0.05)。结论与BUN及Crea相比,CysC有助于早期糖尿病肾病的诊断。Objective To investigate the diagnostic value of serous cystine protease inhibitor C（CysC） in early diabetic nephropathy. Methods Total of 251 cases of early diabetic kidney disease were screened from medical data base of the Second Affiliated Hospital of SUMS（from Jan. 2006 to Dec. 2012） ,according to value of urinous albumin, were divided into group of normal-albumin （UAER〈20μg/min, n = 96）, micro-albumin （ 20 μg/min≤UAER〈200 μg/min, n = 82）, clinical-albumin group （ UAER≥200μg/min, n = 73 ）, and there were 100 healthy volunteers as con- trol group. Serous concentrations of CysC, BUN, and Crea in 4 groups were detected and the parameters were analyzed by ANOVA. Results Value of CysC in normal-albumin group was similar to that in control group（P〉0.05）. However,the value of CysC in micro-albumin group and clinical-albumin group was significantly higher than that in normal-albumin and control group（P〈0.01）. No significant difference had been found in value of serous BUN and Crea among control, normal-albumin and micro-albumin groups（P〉0.05）, and the value of serous BUN and Crea in clinical-albumin group was the highest compared with that in other groups（P〈0.01）. Conclusion Comparing with BUN and Crea,concentration of serous CysC was beneficial for the diagnosis of early diabetic nephropathy.

关 键 词：糖尿病肾病 血清胱氨酸蛋白酶抑制剂C 尿清蛋白 

分 类 号：R373[医药卫生—病原生物学]