右美托咪啶在麻醉恢复室中的临床应用  

Clinical application of dexmedetomidine in anesthesia recovery room

作　　者：皮名芳[1,2] 陈春[1,2] 林雷[1,2] 王顶鸣[1,2] 唐万英[1,2] 侯俊[1,2] 

机构地区：[1]三峡大学第一临床医学院 [2]宜昌市中心人民医院麻醉科,湖北宜昌443003

出　　处：《西部医学》2013年第11期1694-1695,1698,共3页Medical Journal of West China

摘　　要：目的观察右美托咪啶在麻醉恢复室中的临床疗效,探讨其对预防全麻患者术后苏醒拔管期躁动、寒战、恶心、呕吐发生及血流动力学的影响。方法选择择期全麻下行腹腔及盆腔手术患者100例,随机分为观察组(A组)和对照组(B组)各50例。A组在苏醒拔管前静脉缓慢输注右美托咪啶0.5μg/kg,输注时间>10分钟;B组输注等量生理盐水,比较两组全麻术后苏醒拔管期躁动、寒战、恶心、呕吐的发生率及各时段血流动力学的变化情况。结果 A组苏醒期躁动、寒战、恶心明显少于B组(P<0.05);且拔管时、拔管后2、5min平均动脉压(MAP)、心率(HR)也明显低于B组(P<0.05),但与拔管前的MAP、HR比较无显著差异(P>0.05);而B组拔管时、拔管后2、5min的MAP、HR与拔管前差异有统计学意义(P<0.05),但两组各时段血氧饱和度(SpO2)比较差异无显著性(P>0.05)。结论右美托咪啶可有效预防全麻苏醒期躁动、寒战、恶心等不良反应,并能维持苏醒拔管期血流动力学稳定。Objeceive To investigate the clinical efficacy of dexmedetomidine in anesthesia recovery room to make clear the dexmedetomidine on prevention of patient recovery after general anethesia during tracheal extubation inrestlessness,shivering,nausea,vomiting and hemodynamics.Methods 100 patients scheduled for abdominal and pelvic operation under general anesthesia were randomly divided into the observation group （group A,n =50） and control group （group B,n=50）.Group A patients received dexmedetomidine 0.5 μg/kg by vein infusion,the infusion time was more than 10 minutes.Group B patients received normal saline.Comparison of two groups of recovery after general anethesia during tracheal extubation in restlessness,chills,nausea,vomiting and the incidence of hemodynamics changes in each period.Results The restlessness,chills,nausea of group A was obviously less than that of group B （P＜0.01）.At extubation,2 min and 5 min after extubation mean arterial pressure,heart rate of group A decreased compared with that of group B.Conclusion Dexmedetomidine may be effective in the prevention of restlessness,chills,nausea and other adverse reactions during the recovery period of general anethesia,and can maintain the awake extubation period of hemodynmaic stability.

关 键 词：右美托咪啶 麻醉恢复室 不良反应 血流动力学 

分 类 号：R614.2[医药卫生—麻醉学]