白细胞介素17在慢性丙型肝炎患者免疫损伤中的作用  

Effects of inerleukin-17 on immunologic injury of patients with chronic hepatitis C

作　　者：黄建宏[1,2] 凌文辉[1,2] 林心[1,2] 禤彩云[1,2] 郑通明[1,2] 

机构地区：[1]珠海市人民医院 [2]暨南大学附属珠海医院检验科,广东珠海519000

出　　处：《国际检验医学杂志》2013年第21期2819-2820,共2页International Journal of Laboratory Medicine

基　　金：广东省医学科研基金资助项目(A2012614)

摘　　要：目的探讨白细胞介素17(IL-17)在慢性丙型肝炎患者免疫损伤中的作用。方法选择22例慢性丙型肝炎患者作为HCV组,20例健康志愿者作为对照组。分别采用实时聚合酶链反应(RT-PCR)、酶联免疫吸附测定(ELISA)检测血清HCVRNA及IL-17,其余检测指标包括血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TBIL)、凝血酶原时间(PT)、肌酐。结果 HCV组患者血清IL-17水平明显高于对照组(P<0.05)。HCV组患者血清ALT、AST及HCV-RNA与血清IL-17水平显著相关(P<0.05)。结论 IL-17可能参与了慢性丙型肝炎的免疫学发病机制。Objective To investigate the effects of interleukin-17 on immunologic injury of patients with chronic hepatitis C. Methods Twenty-two patients with chronic hepatitis C were selected to serve as HCV group and 20 healthy volunteers as control group. Real time polymerase chain reaction（RT-PCR） and enzyme-linked immunosorbent assay（ELISA） were utilized to detect serum HCV-RNA and IL-17, respectively. The rest detection indexes include alanine aminotransferase（ALT）, aspartate aminotransferase（AST） ,total bilirubin（TBIL）,prothrombin time（PT） and creatinine. Results Serum IL-17 level of patients in HCV group was significant higher than that in control group（P〈0.05）. Serum ALT,AST and HCV-RNA of patients in HCV group showed a marked correlation with serum IL-17 （P〈 0. 05）. Conclusion IL-17 may involved in immunological pathogenesis of chronic hepatitis C.

关 键 词：肝炎病毒属 肝炎 丙型 白细胞介素17 肝功能试验 

分 类 号：R512.63[医药卫生—内科学]