孕中期孕妇血清sEng、sFlt-1联合检测预测子痫前期的探讨  

A study on preeclampsia prediction using combined detection of serum sEng and sFlt-1 in women during their second trimester pregnancy

作　　者：赵小云[1] 尚守亮[1] 黄梅[1] 

机构地区：[1]滨海县中医院检验科,江苏盐城224500

出　　处：《国际检验医学杂志》2013年第21期2850-2851,2853,共3页International Journal of Laboratory Medicine

摘　　要：目的 探讨联合检测孕妇孕中期血清可溶性内皮因子（sEng）、可溶性血管内皮生长因子受体1（sFlt-1）对子痫前期的预测.方法 选择孕25～28周的子痫前期孕妇29例作为子痫前期组,另选择同期妊娠结果正常的42例孕妇作为对照组,采用酶联免疫吸附测定（ELISA）试剂盒检测血清sEng、sFlt-1水平,并将检测结果与子痫前期的发病进行相关性分析.结果 子痫前期组孕妇血清sEng、sFlt-1水平分别为（10.4±1.5）ng/mL、（1 020.3±115.1）ng/L,高于对照组[分别为（2.3±0.6） ng/mL、（289.4±142.3）ng/L],差异有统计学意义（P〈0.01）.sEng与sFlt-1联合检测的敏感性、特异性分别为95.7%、90.9%.结论 血清sEng、sFlt-1的联合检测可有效预测子痫前期的发生.Objective To explore the preeclampsia prediction using combined detection of serum soluble endoglin（sEng） and soluble fmsqike tyrosine kinase receptor 1（sFlt-1） in women during their second trimester pregnancy. Methods Twenty-nine 25 to 28 weeks pregnant women with preeclampsia were selected and served as preeclampsia group while 42 pregnant women with normal pregnancy outcomes in the same period as control group. Enzyme-linked immunosorbent assay（ELISA） kit was adopted to detect serum sEng and sFlt-1 levels,and the correlation analysis between the detection results and preeclampsia occurrence was conducted. Results Serum sEng and sFlt-1 levels of pregnant women in preeclampsia group were （10.4 ±1.5）ng/mL and （1 020.3 ± 115.1 ） ng/L, respectively, which were higher than those in control groupE （ 2.3 ±0.6 ） ng/mL and （ 289.4 ±142.3 ） ng/L, respectively] with statistically significant difference（P（0.01）. The sensitivity and specificity of combined detection of sEng and sFlt-1 were 95.7% and 90.9 %, respectively. Conclusion Combined detection of serum sEng and sFlt-1 can effectively predict the preeclampsia occurrence.

关 键 词：先兆子痫 血管内皮生长因子受体1 可溶性内皮因子 预测 

分 类 号：R714.2[医药卫生—妇产科学]