浙江省诸暨市健康人群流行性脑脊髓膜炎W135、Y群抗体水平分析  

Antibody level against Neisseria meningitidis serogroups W135 and Y among healthy population in Zhuji,Zhejiang

作　　者：阮慧白 陈深侠[1] 谢锦荣 郑飞燕[1] 

机构地区：[1]诸暨市疾病预防控制中心,浙江诸暨311800

出　　处：《疾病监测》2013年第10期815-817,共3页Disease Surveillance

摘　　要：目的通过检测健康人群W135、Y群脑膜炎奈瑟菌人群免疫抗体水平，了解自然感染情况，为流行性脑脊髓膜炎（流脑）预防提供参考依据。方法2011年10月至2012年3月按年龄分层随机抽样，采集浙江省诸暨市0～74岁人群血清1084份，用酶联免疫吸附试验检测流脑W135、Y群多糖抗体IgG含量。结果1084名调查对象流脑W135群抗体阳性率为25．65％，人群保护性抗体比例为11．81％，人群抗体几何平均浓度（GMC）为1．49μg／ml，各年龄组抗体阳性率差异有统计学意义（矿=66．973，P〈0．01），阳性率以30～39岁组为最高（39．66％）；流脑Y群抗体阳性率为10．98％，人群保护性抗体比例为6．55％，人群抗体GMC为1．32μg／ml，各年龄组抗体阳性率差异有统计学意义（X^2=27．832，P〈0．01），阳性率以20—29岁组为最高（17．21％）。结论人群对流脑W135、Y群普遍易感，应加强对脑膜炎奈瑟菌的监测，严防流脑W135、Y群的暴发流行。Objective To understand the natural infection status of Neisseria meningitidis serogroups W135 and Y among healthy population and provide evidence for the prevention and control of epidemic cerebrospinal meningitis. Methods From October 2011 to March 2012. a total of 1084 healthy people aged 0 -74 years were selected trough age- stratified random sampling. Blood samples were taken from them to detect IgG level of N. meningitidis W135 and Y with ELISA. Results The detection rate of antibody to W135 was 25.65%, the proportion of people with protective antibody level was 11.81% and the antibody geometric mean concentration （GMC） was 1.49 p,g/ml. The difference in antibody positive rate in different age group had statistical significance （X2 = 66. 973, P 〈 0. 01 ）. The positive rate in age group 30 -39 years was highest （39. 66% ）. The detection rate of antibody to Y was 10. 98%. The proportion of people with protective antibody level was 6. 55% and the antibody GMC was 1.32 txg/ml. The difference in antibody positive rate in different age group had statistical significance （X2 = 27. 832, P 〈 0.01 ）. The positive rate in age group 20 - 29 years was highest （ 17. 21% ）. Conclusion People are usually susceptible to N. meningitidis W135 and Y. It is necessary to strengthen the surveillance of N. meningitidis to prevent the outbreak of W135 or Y serogroup.

关 键 词：流行性脑脊髓膜炎 W1 35群脑膜炎奈瑟菌 Y群脑膜炎奈瑟菌 抗体水平 

分 类 号：R181.3[医药卫生—流行病学]