泼尼松治疗肾病综合征骨吸收的变化及α-D3的干预作用  

The changes of bone resorption in prednisone treatment of nephrotic syndrome and the intervention of α-D3 on it

作　　者：吴雪平[1,2] 郝丽[1] 刘桂凌[1] 

机构地区：[1]安徽医科大学第二附属医院肾脏内科,合肥230601 [2]蚌埠医学院第一附属医院肾脏内科,蚌埠233004

出　　处：《安徽医科大学学报》2013年第12期1530-1532,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽省卫生厅自然科学研究项目(编号:2008B006)

摘　　要：目的探讨泼尼松(Pred)治疗原发性肾病综合征(PNS)患者骨吸收的变化及α-D3的干预效果。方法①选择确诊为PNS的患者30例作为研究对象,在Pred治疗前(PNS治疗前组)、治疗6周后(PNS治疗6周后组)分别留取血、尿标本检测血全段甲状旁腺素(iPTH)、血钙及尿脱氧吡啶啉(DPD),并与年龄、性别匹配的健康体检者(健康组)28例对照。②30例PNS患者在Pred治疗6周后随机分为Pred组和Pred+α-D3组,2周后两组分别留取血、尿标本检测上述各项指标。结果①PNS治疗前组,尿DPD排泄率明显高于健康组(P<0.05),血iPTH浓度明显高于健康组(P<0.01);血钙浓度与健康组相比,差异无统计学意义。②PNS治疗6周后组尿DPD排泄率明显高于PNS治疗前组(P<0.01),血iPTH浓度明显高于PNS治疗前组(P<0.01);血钙浓度无明显变化。③Pred+α-D3组与Pred组比较,尿DPD排泄率明显降低(P<0.01),血iPTH浓度明显降低(P<0.05),差异有统计学意义;血钙浓度无明显变化。结论α-D3能有效减少PNS患者的骨吸收,从而有效防治骨质疏松症。Objective To discuss the change of bone resorption of primary nephrotic syndrome （PNS） patients with prednisone treatment, and α-D3 effects on it. Methods ① 30 PNS patients diagnosed and 28 healthy people in our hospital were selected; blood and urine samples before and after enough prednisone （prcd） treatment were collected to detect the iPTH, calcium and urinary DPD.② 30 PNS patients after 6 weeks enough prednisone treatment were randomly divided into Pred ＋ α-D3 group and Pred group. Results ① PNS group compared with healthy group, urine DPD excretion rate was significantly increased （P 〈 0. 05 ）, and blood iPTH was significantly increased （ P 〈 0.01 ） ; blood calcium was similar to healthy group. ② PNS patient after treatment with pred compared with that before treatment, urine DPD excretion rate was significantly increased（ P 〈 0. 01 ） , and blood iPTH was significantly increased（ P 〈 0. 01 ）. There was no obvious change in blood calcium. ③Pred ＋ α-D3 group compared with Pred group, urine DPD excretion rate was significantly decreased （P 〈 0.01 ）, and blood iPTH was significantly decreased （ P 〈 0. 05 ）. There was no obvious change in blood calcium. Conclusion α-D3 can effectively reduce bone resorption in PNS patients.

关 键 词：肾病综合征 脱氧吡啶啉 泼尼松 骨吸收 α-D3 

分 类 号：R459.1[医药卫生—治疗学]