MeCP2： Making sense of missense in Rett syndrome  

作　　者：Abhishek Banerjee Esmeralda Romero-Loren Mriganka Sur 

机构地区：[1]The Picower Institute for Learning and Memo- ry, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cam- bridge, MA 02139, USA

出　　处：《Cell Research》2013年第11期1244-1246,共3页细胞研究（英文版）

摘　　要：Fine scale genomic regulation is critical for maintaining genomic integrity and is often disrupted in neurodevelopmental disorders. An intriguing new study reveals the in- tricate biochemical complexity of de novo post-translational modifications of MeCP2, including activity-depen- dent protein-protein interactions that ＇bridge＇ the nuclear receptor co-repressor （NCoR） complex to chromatin and lead to alterations in gene expression that characterize Rett syndrome.

关 键 词：综合征 蛋白质相互作用 决策 翻译后修饰 发育障碍 基因表达 基因组 染色质 

分 类 号：Q51[生物学—生物化学] O225[理学—运筹学与控制论]