银杏叶提取物对老年大鼠ATP酶活性的影响  

Effect of extract of Ginkgo biloba leaves on activities of cerebral ATPase in old rats

作　　者：李梅[1] 邢淑华[1] 崔家勇[1] 

机构地区：[1]徐州医学院药理学教研室,江苏徐州221002

出　　处：《徐州医学院学报》2000年第6期448-450,共3页Acta Academiae Medicinae Xuzhou

摘　　要：目的　观察银杏叶提取物 (extractofGinkgobiloba ,EGB)对老年大鼠ATP酶活性的影响。方法　老年大鼠随机分为 3组 ,分别腹腔注射生理盐水 (NS) 10ml·kg-1、EGB 75mg·kg-1、EGB 15 0mg·kg-1,30min后断头取脑 ,检测大鼠不同脑组织ATP酶的活性。结果　给予EGB后老年大鼠的皮层和海马Na+ -K+ -ATP酶及Ca2 + -ATP酶的活性均较老年对照组高 ,其中 ,EGB高剂量组与老年对照组相比有显著差异 (P <0 .0 1或P <0 .0 5 )。结论EGB能保护脑组织ATP酶的活性 。Objective To investigate the effect of extract of Ginkgo biloba leaves(EGB) on the activities of cerebral ATPase in old rats.?Methods Old rats were randomly divided into 3 groups and injected intraperitoneally(ip) NS(10 ml·kg -1 ) or EGB(75 and 150?mg·kg -1 ). The rats were decapitated 30 min after injection to get the cortex and hippocampus to measure the activities of ATPase.?Results EGB (75 and 150 mg·kg -1 , ip ) remarkably improved the activities of Na +-K +-ATPase and Ca 2+ -ATPase in the cerebral tissues( P <0.01 or P <0.05).?Conclusion These results suggest that EGB provides antiaging effect by improving the activities of ATPase in cerebral tissue.

关 键 词：银杏叶提取物 ATP酶 活性 老年大鼠 抗衰老作用 

分 类 号：R969[医药卫生—药理学]