山核桃叶总黄酮苷元抗炎镇痛作用的研究  

Study on Anti-inflammatory and Analgesic Effects of Total Flavonoid Aglycon from Leaves of Carya Cathayensis Sarg

作　　者：张坤[1] 沈勇[1] 徐敏[1] 刘楠楠[1] 田莎莎[1] 金波[1] 蒋福升[1] 杨汝春[1] 丁志山[1] 

机构地区：[1]浙江中医药大学,杭州310053

出　　处：《浙江中医药大学学报》2013年第10期1226-1229,1239,共5页Journal of Zhejiang Chinese Medical University

基　　金：国家自然科学基金(81303258);浙江省卫生厅科研基金(2012KYB136);浙江省大学生科技创新活动计划资助项目(2012R410057)~~

摘　　要：[目的]研究山核桃叶总黄酮苷元的抗炎镇痛作用。[方法]将60只小鼠随机分为空白组,溶媒对照组,阴性组,山核桃叶总黄酮低、中、高剂量组。采用小鼠扭体实验和小鼠福尔马林实验研究山核桃叶总黄酮苷元的镇痛作用,通过小鼠耳廓肿胀实验和棉球肉芽肿胀实验研究山核桃叶总黄酮苷元的抗炎作用。[结果]山核桃叶总黄酮苷元中剂量组、高剂量组能明显减少醋酸致小鼠扭体次数;对福尔马林引起的小鼠疼痛也有明显的抑制作用;高剂量组对二甲苯致小鼠耳廓肿胀、棉球致小鼠肉芽肿胀均有明显的抑制作用。[结论]山核桃叶总黄酮苷元具有明显的抗炎镇痛作用。[Objective]To study the analgesic effect and anti-inflammatory effect of the total flavonoid aglycon from leaves of Carya Cathayensis Sarg. [Methods] 60 mice were randemly divided into control group, medium group, positire group, the low, middle and high groups. Dimethyl benzene-in-duced acute ear swel ing model and cotton bal induced increased granulation swel ing model were carried out to observe the anti-inflammatory effects of the total flavonoid aglycon from leaves of Carya cathayensis Sarg. And the analgesic effect of the total flavonoid agalycon was evaluated by pain experi-ments induced by glacial acetic acid and formalin in mice.[Results]The total flavonoid aglycon from leaves of Carya Cathayensis Sarg.（25 mg·kg^-1, 50 mg· kg^-1） could significantly relieve the pain caused by glacial acetic acid and by formalin. It also showed obvious inhibitory effects on the increased granulation swel ing induced by cotton bal , and dimethyl benzene-induced ear swel ing in mice on the dosage 50 mg·kg^-1. [Conclusion]The total flavonoid aglycon from leaves of Carya Cathayensis Sarg showed anti-inflammatory and analgesic effects in the study.

关 键 词：山核桃 总黄酮苷元 抗炎 镇痛 

分 类 号：R331[医药卫生—人体生理学]