化痰行瘀汤对肝纤维化大鼠血清肝功能及透明质酸含量的影响  

Effect of Hua Tan Xing Yu Decoction on Hepatic Function and the Serum of Hyaluronic Acid in Hepatic Fibrosis Rats

作　　者：陈国中[1] 徐珊[2] 张永生[2] 朱飞叶[2] 

机构地区：[1]浙江省立同德医院,杭州310012 [2]浙江中医药大学

出　　处：《浙江中医药大学学报》2013年第10期1236-1239,共4页Journal of Zhejiang Chinese Medical University

基　　金：浙江省金华市科技局2010年资助项目(2010-3-053)~~

摘　　要：[目的]通过实验研究观察化痰行瘀汤对肝纤维化的疗效,并进一步探讨其抗纤维化的作用机制。[方法]60只Wistar大鼠随机分为正常对照组、模型对照组、化痰行瘀汤低、中、高剂量组、复方鳖甲软肝片组6组,每组10只。采用皮下注射四氯化碳(CCl4)橄榄油溶液复制肝纤维化模型,采用全自动生化仪检测血清肝功能,放免法检测血清透明质酸含量。[结果]与模型对照组比较,化痰行瘀汤高剂量组可明显降低血清天冬氨酸氨基转移酶含量(P<0.05);化痰行瘀汤中、高剂量组可明显降低血清透明质酸含量(P<0.05)。[结论]化痰行瘀汤对实验性肝纤维化大鼠具有护肝、抗纤维化的功效。[Objective]To observe the therapeutic effects of Hua tan xing yu（HTXY） decoction on experimental hepatic fibrosis and explore its possible mechanism. [Methods]60 Wistar rats were randomly divided into 6 groups：normal control group,model control group, HTXY decoction groups of low-dose,middle-dose and high-dose ,and Fu fang bie jia ruan gan pil group. The hepatic fibrosis model was induced by subcutaneous injection of carbon te-trachloride（CCL4） olive oil solution. The serum of hepatic function and hyaluronic acid（HA） was determined by automatic biochemical analyzer and ra-dioimmunoassay respectively. [Results]As compared with model control group, the serum of aspartate aminotransferase（AST） was significantly decreased in the HTXY decoction groups of high-dose（P〈0.05） and the serum of HA level was significantly decreased in the HTXY decoction groups of middle-and high-dose（P〈0.05）.[Conclusion] HTXY decoction could improve hepatic function and al eviate hepatic fibrosis.

关 键 词：化痰行瘀汤 肝纤维化 肝功能 透明质酸 

分 类 号：R331[医药卫生—人体生理学]