肿瘤坏死因子对糖代谢的作用  

The effect of tumor necrosis factor on blood glucose

作　　者：谢自敬[1] 鲜牡丝.肉孜 艾比拜[1] 王宁[1] 樊勇[1] 苏丽娅[1] 胡尔西达.牙库甫达毛拉 张伟[2] 

机构地区：[1]新疆医科大学第一附属医院干五科,新疆乌鲁木齐830054 [2]新疆医科大学第一附属医院检验科,新疆乌鲁木齐830054

出　　处：《新疆医科大学学报》2000年第4期345-347,共3页Journal of Xinjiang Medical University

摘　　要：目的 :研究肿瘤坏死因子 (TNF)对血糖的影响。方法 :对 5组不同情况的实验室检测资料进行多因素回归分析。 结果 :人体血循环中 TNF在调整了年龄、胰岛素等变量的影响之后 ,仍独立的影响着代谢综合征患者血糖浓度及血胰岛素浓度。这与动物实验及体外组织培养证实的 TNF抑制胰岛素受体作用相吻合。结论Objective: To study the effect of tumor necrosis factor(TNF) on blood glucose. Method: Multifactor retrospective analysis was performed on laboratory data of 5 groups with different situations (disorders and normal control).Result: After standardization in age and insulin, serum TNF still affected the blood glucose and insulin levels of X syndrome patients; this result was concordant with animal experiment and tissue cultivation in vitro, which verified that TNF inhibits the insulin receptor. Conclusion: TNF has important negative role on blood glucose regulation.

关 键 词：肿瘤坏死因子 血糖调节 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]