血脉通胶囊与卡马西平联用对癫痫模型小鼠的保护作用  

Protective Effects of Xuemaitong Capsules Combined with Carbamazepine on Epilepsy Model Mice

作　　者：焦洋[1] 魏立明[2] 邱雯[2] 

机构地区：[1]兰州大学第二临床医学院,兰州730000 [2]兰州大学第二医院药学部,兰州730030

出　　处：《中国药房》2013年第43期4057-4059,共3页China Pharmacy

摘　　要：目的:研究血脉通胶囊与卡马西平(CBZ)联用对癫痫模型小鼠的保护作用。方法:第1、3、5、8、10天腹腔注射戊四唑(PTZ,45 mg/kg),第12天腹腔注射PTZ(75 mg/kg)以复制小鼠癫痫模型。实验分为模型(等容生理盐水)组、CBZ(120 mg/kg)组、联合用药(CBZ 120 mg/kg+血脉通胶囊500 mg/kg)组。除第12天外,每次腹腔注射PTZ前30 min灌胃给药。计算小鼠轻、重度发作率和死亡率,记录小鼠癫痫轻度发作潜伏期、重度发作持续时间、发作等级,并观察脑组织病理切片。结果:与模型组比较,CBZ组与联合用药组小鼠重度发生率、死亡率显著降低,轻度发作潜伏期显著延长,重度发作持续时间显著缩短,发作等级显著降低(P<0.01),小鼠脑组织的损伤明显减轻。与CBZ组比较,联合用药组以上指标均显著改善(P<0.05)。结论:血脉通胶囊和CBZ联用对小鼠PTZ慢性点燃有明显的抑制作用。OBJECTIVE： To study the protective effects of Xuemaitong capsules combined with carbamazepine （CBZ） on epi- lepsy model mice. METHODS： Mice were given intraperitoneal injection of pentylenetetrazole （PTZ, 45 mg/kg） on 1st, 3rd, 5th, 8th and 10th day, and then given intraperitoneal injection of PTZ （75 mg/kg） on 12th day to induce epilepsy kindling model. Mod- el mice were divided into model group （constant volume normal saline）, CBZ group （120 mg/kg） and drug combination group （CBZ 120 mg/kg＋Xuemaitong capsules 500 mg/kg）. They were given relevant medicines intragastrically 30 min before modeling except 12th day. The mild attack rate, the servere attack rate, death rate were calculated.The latent period of mild attack,the duration of servere attack, attack level were recorded, and pathological section of cerebral tissue was observed. RESULTS： Compared with model group, the servere attack rate and death rate were decreased significantly, the latent period of mild attack was prolonged signif- icantly,the duration of servere attack was shortened significantly, attack level was decreased significantly（P〈0.01）. The damage of cerebral tissue was reduced significantly in CBZ group and drug combination group~ Compared with CBZ group, the index were better in drug combination group （P〈0.05）. CONCLUSIONS： CBZ combined with Xuemaitong capsules can inhibit PTZ-kindling seizures in mice.

关 键 词：血脉通胶囊 戊四唑 癫痫 卡马西平 

分 类 号：R285[医药卫生—中药学] R742.1[医药卫生—中医学]