转化医学下的创伤后应激障碍  

Translational Medicine in Post-Traumatic Stress Disorder

作　　者：刘伟志[1] 刘涛生[1] 王伟[1] 严进[1] 

机构地区：[1]第二军医大学心理与精神卫生学系,上海200433

出　　处：《心理科学进展》2013年第11期1976-1982,共7页Advances in Psychological Science

基　　金：国家科技部重大专项(NO:2010ZXJ0900X-002);上海市卫生局课题(NO:2012172);国家科技部支撑计划项目(NO:2009BAI77B04);军队心理卫生科研专项课题(NO:12XLZ211);上海市教委科研创新重点项目(NO:11ZS79)

摘　　要：创伤后应激障碍(Post-traumatic stress disorder,PTSD)是由于经历或者目睹创伤性事件而导致的心理障碍,是本世纪最主要的公共健康卫生问题之一。转化医学是指将医学等基础研究成果迅速且有效的转化为临床,然后再将临床应用结果反馈并指导基础研究。在转化医学背景下,PTSD研究发现:在生物学方面,下丘脑垂体肾上腺轴和交感肾上腺髓质系统参与PTSD病理生理过程,PTSD患者体内血清皮质醇水平发现下降;在脑机制方面,海马、杏仁核以及内侧前额叶皮质一起参与恐惧反应神经环路的组建,在恐惧消除中起着关键作用。并发现了几个预防和治疗PTSD的生物学和行为途径。但是,目前PTSD仍面临治疗难的窘境,基础性研究成果转化应用尚不充分。因此,加速PTSD转化研究将成为下一步关注的重点。Post-traumatic stress disorder （PTSD） is characterized mainly by symptoms of re-experiencing, avoidance and hyperarousal as a consequence of catastrophic and traumatic events that are distinguished from ordinary stressful life events. The incidence of PTSD is one of the important public health care in this century. Translational medicine is intended to facilitate the transition of basic science results to clinical practice, and thereby sharing major aspects of clinical studies. Under the background of translational medicine, Previously studies found that in biological field hypothalamic-pituitary-adrenal （HPA） and sympathetic-adrenal-medullary （SAM） played important roles in the pathophysiological of PTSD, and the level of cortisol in PTSD patients was decreased; Hippocampus, amygdala, and the medial prefrontal cortex were involved in the fear response of neural circuits and played a key role in fear extinction underlying the mechanism of brain function, theoretically biological preventive approaches of PTSD are emerging. However, the treatment of PTSD still encounters with various difficulties. The translation from basic science research into practice clinical applications would become a focus in the future studies of PTSD.

关 键 词：创伤后应激障碍 转化医学 应激 

分 类 号：R395[哲学宗教—心理学]