超声观察Ⅱ型糖尿病胃动力及西沙比利对其改善作用  

Ultrasonography for gastric emptying function in patients with typeⅡdiabetes mellitus and therapeutic effect of cisapride on diabetic gastroparesis

作　　者：高方[1] 周华[2] 穆红霞[3] 周 琳[1] 汪吉仪[1] 程天明[4] 

机构地区：[1]第一军医大学南方医院内分泌科,广东广州510515 [2]第一军医大学南方医院超声科,广东广州510515 [3]第一军医大学南方医院外科教研室,广东广州510515 [4]第一军医大学南方医院消化研究所,广东广州510515

出　　处：《第一军医大学学报》2000年第6期534-535,共2页Journal of First Military Medical University

摘　　要：目的 探讨Ⅱ型糖尿病患者胃液排空功能，同时观察西沙比利对糖尿病胃轻瘫的疗效。方法 应用超声检查对22例正常组及20例糖尿病患者的胃液半排空时间进行比较，并用西沙比利（10 mg tid）治疗其中11名有胃轻瘫的病人，4周后复查对照。结果 正常组胃液半排空间为（t1/2）（14.80±4.35）min，Ⅱ型糖尿病组的胃半排空时间为（28.00±8.94）min，二者之间有显著的差异。口服西沙比利后11名患者的胃半排空时间由（33.64±5.05）min减至（20.91±5.39）min。结论 糖尿病患者胃排空有明显的障碍，西沙比利可改善糖尿病胃轻瘫，本实验为糖尿病人临床应用西沙比利治疗提供了理论依据。Objective To investigate the gastric emptying function in patients with typeⅡdiabetic gastroparesis. Methods The gastric half-emptying time of liquid meals was measured by B-mode ultrasonography in 20 diabetic patients and 22 healthy subjects. Eleven diabetic patients with gastroparesis received cisapride at an oral single daily dose of 30 mg/d and were reexamined at the end of 4-week treatment course. Results The gastric half emptying time was (14.80±4.35) min in normal subjects and (28.00±8.94) min in diabetic patients. Significantly delayed gastric emptying was found in diabetic patients. The gastric half-emptying time was decreased from (33.64±5.05) min to (20.91±5.39) min (P<0.01) in 11 patients after cispride therapy. Conclusion The gastroparesis is common in patients with typeⅡ diabetes and cisapride has favorable effect on diabetic gastroparesis.

关 键 词：胃轻瘫 超声检查 Ⅱ型糖尿病 西沙比利 胃动力 

分 类 号：R587.1[医药卫生—内分泌]