多孔P(NIPAm-co-AAm)水凝胶对蛋白质控制释放的研究  

Study on drug releasing properties of porous P(NIPAm-co-AAm) hydrogels

作　　者：杨桔[1,2] 

机构地区：[1]西南政法大学刑事侦查学院,重庆401120 [2]重庆高校物证技术工程研究中心,重庆401120

出　　处：《功能材料》2013年第21期3085-3088,共4页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(51102200);重庆市教委科学技术研究资助项目(KJ130108;KJ120106);重庆高校创新团队建设计划资助项目(KJTD201301);西南政法大学校级资助项目(2011-XZQN11)

摘　　要：采用冷冻聚合法制备了多孔结构的P(NIPAm-co-AAm)智能水凝胶,选用牛血清白蛋白(BSA)为模型药物分子,通过后包裹技术负载蛋白质药物,考察了多孔水凝胶中蛋白质药物的载药量和体外释放行为,研究了不同干燥处理方法对载药后水凝胶的药物控释性能的影响,并且与传统方法制备的P(NIPAmco-AAm)水凝胶进行了药物控释性能对比实验。实验结果表明,在凝胶中引入多孔结构使得P(NIPAm-coAAm)水凝胶的药物载药量和释放量得到了显著的提高。不同的干燥处理方法对多孔P(NIPAm-co-AAm)水凝胶的药物释放影响很大,载药后的凝胶采用冰箱冷冻干燥处理,可使蛋白质药物有较好的缓释效果。Porous poly （N-isopropylamide-co-acrylamide） [_ P （NIPAm-co-AAm） J hydrogels were preparect Dy freezing polymerization method. With bovine serum albumin （BSA） as the model drug, it was loaded into por- ous P （NIPAm-co-AAm） hydrogel by post-fabrication encapsulation technique. The loading efficiency and re- lease ratio of model drug were investigated. The influence of different dry processing method on the controlled drug release properties of the drug-loaded hydrogel was also studied. The results showed that creating an inter- connecting pore structure within the hydrogel matrices was an effective strategy to improve the drug loading ef- ficiency and the cumulative released amount. In vitro BSA release from the hydrogels exhibited that dry pro- cessing method played a dominant role in the controlled drug release properties of P（NIPAm-co-AAm） hydro- gel. The drug-loaded hydrogel with the refrigerator freeze-drying treatment showed better sustained drug re- lease of protein drugs.

关 键 词：多孔 温敏水凝胶 N-异丙基丙烯酰胺 控制释放 

分 类 号：R943[医药卫生—药剂学]