原发性视网膜色素变性患眼自身荧光特征及其与视野改变的关系  

Characteristics of fundus autofluorescence in primary retinitis pigmentosa and its relationship with visual fields

作　　者：李慧[1] 谢娟[2] 侯佳[2] 常欣[2] 师燕芸[2] 程娟[2] 栗改云[2] 申仲华[2] 郑太[2] 贾亚丁[2] 

机构地区：[1]山西医科大学,太原030002 [2]山西省眼科医院

出　　处：《中华眼底病杂志》2013年第6期585-588,共4页Chinese Journal of Ocular Fundus Diseases

摘　　要：目的观察原发性视网膜色素变性（RP）患眼短波长自身荧光（SW—AF）和近红外自身荧光（NIR—AF）特征以及与视野改变的相关性。方法临床检查确诊的原发性RP患者12例24只眼纳入研究。其中，男性9例18只眼，女性3例6只眼。年龄15～69岁，平均年龄（35．33±15．03）岁。均行眼底彩色照相、SW—AF、NIR—AF、电脑视野、光相干断层扫描（OCT）检查。结果SW—AF、NIR—AF检查结果均显示，眼底后极部均有大小不等的强荧光环。SW—AF强荧光环内部弱荧光区域面积与NIR—AF强荧光区域面积正相关（r=0．662，P％0．05）。0CT检查证实强荧光环外的区域光感受器内外节连接（IS／OS）层和外界膜断裂、外核层变薄及色素上皮变薄萎缩。周边部视网膜骨细胞样色素沉着在SW—AF和NIR-AF中均为无荧光，眼底斑块样改变区域在SW—AF中同一位置表现为斑驳样弱荧光。SW—AF强荧光环与视野具有正相关（r=0．492，P〈0．05）。结论RP患者视野与SW—AF强荧光环内区域大小相关，且SW—AF强荧光环内区域与NIR—AF强荧光区域视网膜结构正常。Objective To observe the characteristics of fundus autofluorescence （AF） in short wavelength AF （SW-AF） and Near Infrared AF （NIR-AF）, and their relationship with visual fields. Methods Twelve patients （24 eyes） with primary RP were enrolled in this study. The patients included nine males （18 eyes） and three females （six eyes）. The patients aged from 15 to 69 years, with a mean age of （35.33±15.03） years. All the patients were examined for color photography, SW-AF, NIR-AF, visual fields and optical coherence tomography examination. Results There were hyper-AF ring of varying sizes in posterior pole by SW-AF and NIR-AF examinations. The area of hypo-AF which located in SW-AF hyper- AF ring had a positive correlation with the area of hyper-AF in the NIR-AF （r=0. 662,P^0.05）. OCT showed that outside the hyper-AF ring, there were disconnected inner segment/outer segment （IS/OS） junction and external limiting membrane, and thinned outer nuclear layer and retinal pigment epithelium. Peripheral retinal osteocytes-like pigmentation showed non fluorescence in SW-AF and NIR-AF. The plaque- like area showed mottled and low fluorescence examined by SW-AF. SW-AF hyper-AF ring had a positive correlation with visual fields （r=0. 492,P〈0.05）. Conclusions The area of hypo-AF inside of the SW-AF hyper-AF ring is related to visual fields in RP patients. The retinal structures in the hypo-AF area inside of the SW-AF hyper-AF ring, and in the NIR-AF hyper-AF region are normal.

关 键 词：色素性视网膜炎 诊断 体层摄影术 光学相干 视野 

分 类 号：R774.13[医药卫生—眼科]