鼻腔盐水冲洗和局部应用激素对变应性鼻炎的治疗价值  

Influence of local irrigation and steroid treatment on allergic rhinitis

作　　者：蔺林[1] 严文洪[1] 赵霞[1] 程雷[2] 

机构地区：[1]复旦大学附属华山医院耳鼻咽喉头颈外科,上海200040 [2]南京医科大学第一附属医院耳鼻咽喉科

出　　处：《中国中西医结合耳鼻咽喉科杂志》2013年第5期351-356,共6页Chinese Journal of Otorhinolaryngology in Integrative Medicine

基　　金：上海市卫生局科研课题计划项目(20114145)资助

摘　　要：目的通过研究鼻腔局部冲洗和应用激素对变应性鼻炎的影响,探讨治疗变应性鼻炎的恰当方式。方法临床方面采用视觉模拟评分量表(VAS)和迷你型鼻结膜炎生活质量问卷(MiniRQLQ)评估健康对照组及各实验组临床症状的改变,实验室方面采用瑞典Pharmacia UniCAP 100型免疫荧光定量分析系统检测健康对照组及各实验组血清中屋尘螨特异性IgE(sIgE)和嗜酸粒细胞阳离子蛋白(ECP)的含量的改变。结果单纯鼻腔冲洗组(A组)和局部激素溶液冲洗组(D组)无论是临床方面还是实验室方面评估都没有显著性改变,而单纯鼻喷激素组(B组)和鼻喷激素联合冲洗组(C组)两方面均有统计学差异,并且后两组间比较无显著性差异。结论单纯鼻喷激素或鼻喷激素联合冲洗是治疗变应性鼻炎的恰当方式,单纯鼻腔冲洗或局部激素溶液冲洗在治疗变应性鼻炎方面只能作为辅助手段。Objective To investigate the influence of local irrigation and hormone treatment on allergic rhinitis and to confirm the appropriate therapies of allergic rhinitis.Methods Using the visual analogue scale （VAS） and Mini Juniper Rhinoconjunctivitis QoL Questionnaire （MiniRQLQ） to assess the symptoms among the control group and the various intervention groups in clinic and applying quantitative analysis of immunofluorescent to detect the contents of house dust mite specific IgE （sIgE） and eosinophil cationic protein （ECP） with Pharmacia UniCAP 100 system among the control group and the various intervention groups in experiment.Results TThere were no significant differences both in the single nasal irrigation group （A group） and in the local hormone solution irrigation group （D group） whether in clinic or in experiment.However,statistical significant differences appeared in the single nasal spray group （B group） and in the combined treatment of nasal irrigation and spray （C group）.Furthermore,C group was not better than B group.Conclusion Single nasal spray and combined treatment of nasal irrigation and spray are all the appropriate therapies of allergic rhinitis.Single nasal irrigation and local hormone solution irrigation may only play a role in adjunct treatment of allergic rhinitis.

关 键 词：鼻腔 局部冲洗 激素 变应性鼻炎 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]