乙醇引起大鼠低温反应与棕色脂肪组织产热变化的关系  

Ethanol Induced Hypothermic Response in Rats and Its Relationship with the Thermogenic Activity of Brown Adipose Tissue

作　　者：昝旺[1] 杨永录[1] 王诚[1] 沈字玲[1] 

机构地区：[1]成都医学院体温与炎症四川省高校重点实验室,610500

出　　处：《医学研究杂志》2013年第10期65-68,共4页Journal of Medical Research

基　　金：四川省教育厅科研基金资助项目(12ZB204);成都医学院学科建设项目专项基金资助项目(CYXK2012003)

摘　　要：目的研究乙醇引起低温反应与棕色脂肪组织（brownadiposetissue，BAT）产热变化的关系。方法实验用成年雄性SD大鼠，在22℃环境温度下，明暗时间各12h，昼光时间为上午6时～下午6时，用无线遥控技术测量体核温度、BAT温度、动物活动和尾部皮肤温度。上午10时给大鼠腹腔注射乙醇（3g／kg）或生理盐水。结果腹腔注射乙醇后能快速引起BAT温度降低，并且伴有体核温度明显降低反应，同时大鼠的活动也出现降低反应。另外，乙醇也能引起尾部皮肤温度明显降低。结论乙醇引起大鼠低温与其能抑制BAT产热和降低动物活动有关。Objective To determine ethanol - induced hypothermie response and its relationship with changes in the thermogenic ac- tivity of brown adipose tissue（BAT）. Methods The core temperature, BAT temperature, motor activity and tail skin temperature were measured by telemetry in adult male Sprague -Dawley rats at an ambient temperature of 22℃ during a 12h light：12h dark photoperiod. At 10：00 am the rats were dosed intraperitoneally with ethanol （3g/kg） or saline. Results Intraperitoneal injection of ethanol could elicit rapid drop in BAT temperature cembined with a marked decrease in core temperature, and could also decrease motor activity in rats. In addition, ethanol also caused a marked decrease in tail skin temperature. Conclusion Our data indicated that ethanol - induced hypo- thermia attributed to the suppression of BAT thermogenesis and the decrease decrease motor activity in rats.

关 键 词：乙醇 低温 体核温度 棕色脂肪组织温度 

分 类 号：R339.38[医药卫生—人体生理学]