金属基质蛋白酶9与脓毒症性肺损伤关系的研究  

Relationslip between Matrix Metalloproteinase 9 and Sepsis-induced Lung Injury

作　　者：陈昊 乔丽旻 张丽葳[3] 张莉芬[3] 李俊[3] 王毅[3] 奚希相[3] 周超 

机构地区：[1]上海市浦东新区周浦医院呼吸内科,201318 [2]上海联洋社区卫生服务中心内科,200135 [3]上海市第七人民医院急诊科,200137

出　　处：《医学研究杂志》2013年第10期85-88,共4页Journal of Medical Research

基　　金：周浦医院2012年院级重点学科基金资助浦东新区卫生科技项目青年基金资助(PW2011B-4)

摘　　要：目的研究MMP-9在急性肺损伤形成及预后评价的临床价值。方法选取符合《2008国际严重脓毒症和脓毒性休克治疗指南》诊断的脓毒症患者62例。观察患者是否出现肺损伤,并进行APACHEⅡ及SOFA评分。检测MMP-9、PCT、CRP血清水平。结果 AL/ALI/ARDS组MMP-9血清浓度比较NAL有明显升高并有统计学差异。对肺损伤患者中AL/ALI组MMP-9/CRP与APACHEⅡ1D、7D/SOFA1D、7D评分进行相关性分析,差异均无统计学意义(P>0.05)。AL/ALI组PCT与APACHEⅡ1D/SOFA1D评分进行相关性分析,呈正相关,差异有统计学意义(P<0.05)。结论 MMP-9血清水平与脓毒性肺损伤的发生有一定的相关性,MMP-9在脓毒性肺损伤的发生过程中可能有有特殊的意义。MMP-9能投入临床应用预估脓毒性肺损伤的发生。本研究尚未发现MMP-9预测脓毒性肺损伤患者转归的价值。Objective To investigate the role of MMP - 9 in acute lung injury and prognostic evaluation. Methods Patients were selected into the group according the 2008 International Severe Sepsis and Septic Shock Treatment Guidelines Diagnosis of Sepsis. We ob- served whether the patient would be with acute lung injury. Meanwhile we completed APACHE II and SOFA scores, detected MMP -9, PCT, CRP serum levels. Results The expression level of MMP -9 was significantly increased between AL/AL1/ARDS group and NAL group and the difference was significant. We conducted correlation analysis in the group AI/ALI MMP -9/CRP with APACHE ]] 1D, 7D/SOFA1D 7D . There was no statistically significant （P 〉 0.05）. There was a positive correlation and statistically significant （P 〈 0.05） in PCT,APACHE I] 1D score,SOFA1D score between AL and ALI group. Conclusion There is a certain correlation betwee. MMP -9 serum levels and septic lung injury, MMP -9 in septic lung injury process may have a special meaning. MMP -9 may be put in- to clinical application to estimate the incidence of septic lung injury. We have not found the value of MMP - 9 in predicting outcome of septic lung injury.

关 键 词：脓毒症肺损伤MMP-9 PCT CRP 

分 类 号：R563[医药卫生—呼吸系统]