Up-regulation of Ras/Raf/ERK1/2 signaling in the spinal cord impairs neural cell migration, neurogenesis, synapse formation, and dendritic spine development  

作　　者：Cao Fu-jiang Zhang Xu Liu Tao Li Xia-wen Malik, Mazar Feng Shi-qing 

机构地区：[1]Tianjin Med Univ, Gen Hosp, Dept Orthopaed, Tianjin 300052, Peoples R China [2]Univ Lancaster, Grad Sch, Lancaster LA1 4YQ, England

出　　处：《Chinese Medical Journal》2013年第20期3879-3885,共7页中华医学杂志（英文版）

摘　　要：Background The Ras/Raf/ERK1/2 signaling pathway controls many cellular responses such as cell proliferation, migration, differentiation, and death. In the nervous system, emerging evidence also points to a death-promoting role for ERK1/2 in both in vitro and in vivo models of neuronal death. To further investigate how Ras/Raf/ERK1/2 up-regulation may lead to the development of spinal cord injury, we developed a cellular model of Raf/ERK up-regulation by over- expressing c-Raf in cultured spinal cord neurons （SCNs） and dorsal root ganglions （DRGs）.Background The Ras/Raf/ERK1/2 signaling pathway controls many cellular responses such as cell proliferation, migration, differentiation, and death. In the nervous system, emerging evidence also points to a death-promoting role for ERK1/2 in both in vitro and in vivo models of neuronal death. To further investigate how Ras/Raf/ERK1/2 up-regulation may lead to the development of spinal cord injury, we developed a cellular model of Raf/ERK up-regulation by over- expressing c-Raf in cultured spinal cord neurons （SCNs） and dorsal root ganglions （DRGs）.

关 键 词：Ras/Raf/ERK1/2 spinal cord injury  neural circuit imbalances  signaling pathway 

分 类 号：Q25[生物学—细胞生物学] Q257