Ischemic preconditioning produces more powerful anti- inflammatory and cardioprotective effects than limb remote ischemic postconditioning in rats with myocardial ischemia-reperfusion injury  

作　　者：Zhang Jia-qiang Wang Qiang Xue Fu-shan Li Rui-ping Cheng Yi Cui Xin-long Liao Xu Meng Fan-min 

机构地区：[1]Zhengzhou Univ, Dept Anesthesiol, Peoples Hosp, Zhengzhou 450003, Henan, Peoples R China [2]Peking Univ, Peoples Hosp, Dept Anesthesiol, Beijing 100044, Peoples R China [3]Chinese Acad Med Sci, Plast Surg Hosp, Dept Anesthesiol, Beijing 100144, Peoples R China [4]Peking Union Med Coll, Beijing 100144, Peoples R China

出　　处：《Chinese Medical Journal》2013年第20期3949-3955,共7页中华医学杂志（英文版）

摘　　要：Background Both ischemic preconditioning （IPC） and limb remote ischemic postconditioning （LRIPOC） have been shown to possess significantly different cardioprotective effects against the myocardial ischemia reperfusion injury （IRI）, but no study has compared the anti-inflammatory effects of IPC and LRIPOC during myocardial IRI process. We hypothesized that IPC and LRIPOC would produce different anti-inflammatory effects in an in vivo rat model with myocardial IRI.Background Both ischemic preconditioning （IPC） and limb remote ischemic postconditioning （LRIPOC） have been shown to possess significantly different cardioprotective effects against the myocardial ischemia reperfusion injury （IRI）, but no study has compared the anti-inflammatory effects of IPC and LRIPOC during myocardial IRI process. We hypothesized that IPC and LRIPOC would produce different anti-inflammatory effects in an in vivo rat model with myocardial IRI.

关 键 词：myocardial ischemia-reperfusion injury ＂ inflammatory response ＂ ischemia preconditioning ＂ limb remote!schemic postconditioning 

分 类 号：Q95-33[生物学—动物学] Q463