汉-英非熟练晚双语者语言区定位研究  

Brain mappings in non-fluent late Chinese-English bilinguals

作　　者：高寒[1] 白红民[1] 韩立新[2] 李天栋[1] 王伟[1] 刘一兵[1] 林健[1] 曾翾[1] 王国良[1] 王玉宝[1] 王丽敏[1] 张小鹏[1] 王伟民[1] 

机构地区：[1]广州军区广州总医院神经外科,510010 [2]广州军区广州总医院磁共振室,510010

出　　处：《中华外科杂志》2013年第11期1021-1024,共4页Chinese Journal of Surgery

摘　　要：目的探讨汉一英非熟练晚双语者的皮层语言区定位特点。方法6例汉一英非熟练晚双语者，因语言区肿瘤需行唤醒手术，术前应用BOLD—fMRI执行单纯图片命名、图片动词联想及词语语义判断任务，术中应用直接皮层电刺激技术（DCS）作为语言功能定位的金标准定位汉、英语言区，对BOLD—fMRI的3种语言任务确定的激活区与术中DCS证实的语言区进行McNemer检验。结果6例患者术中共刺激了71个点，发现语言区16个（22．5％）。特定语言区3个，其中特定英语语言区2个，特定汉语语言区1个。BOLD—fMRI执行的3种语言任务与金标准DCS结果的比较，差异均有统计学意义（P〈0．017）。3种术前语言任务中动词联想任务的一致率最高为40．9％（95％CI：30．2％～52．5％）。结论对于汉一英非熟练晚双语者，术中DCS可证实其优势半球内存在特定语言区，而BOLD—fMRI语言区定位不能替代。Objective To discuss the distribution characteristics of language areas in Chinese- English non-fluent late bilinguals. Methods Six Chinese-English bilinguals with eloquent tumors underwent awake-surgeries. The activated areas of BOLD-fMRI were obtained as the patients performed pure naming, verb generation, and abstract/concrete judgment tasks. Direct cortical stimulation （DCS） as the golden standard of language mapping were performed during awake-surgeries on the exposed cortical areas. BOLD- fMRI results of 3 language tasks were compared with DCS results. The statistical method was McNemer. Results Sixteen positive sites （22. 5% ） were comfirmed out of 71 stimulations. There were 3 specific language sites, in which 2 sites were specific English sites and 1 site was specific Chinese site. When activated areas of BOLD-fMRI were compared with the DCS results, verb generation task had the highest concordance rate 40. 9% （95% CI：30. 2%-52. 5% ）. There were significant differences between the results of BOLD-fMRI and DCS of all 3 bilingual tasks （ P 〈 0. 017）. Conclusions There are specific language areas in Chinese-English non-fluent late bilinguals. The BOLD-fMRI language mapping could not substitute DCS in the context of mapping language areas in bilinguals.

关 键 词：大脑皮质 多种语言能力 语言障碍 深部脑刺激法 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]