慢性肝病患者血清C-IVLN及HA与TNFα关系的研究  

Study of Relation of Type IV Collagen Laminin and Hyaluronic Acid with Tumor Necrosis Factor α in the Sera of Patients with Chronic Liver Disease

作　　者：夏玲玲[1] 吴永贵[2] 李旭[1] 

机构地区：[1]安徽医科大学第一附属医院传染科,230032 [2]上海医科大学华山医院肾内科

出　　处：《皖南医学院学报》2000年第3期181-182,184,共3页Journal of Wannan Medical College

摘　　要：采用放射免疫法测定 85例慢迁肝 (CPH)、慢活肝 (CAH)和肝硬化 (LC)患者血清C IV、LN、HA及TNFα水平。发现各组肝病患者血清C IV、HA含量均明显高于正常对照组 (P <0 0 1) ,LN在CAH和LC组也明显高于正常对照组 (P <0 0 1) ,这些指标均随着肝纤维化程度进行性增加 ,TNFα含量以CAH最高 ,LC次之。另外血清TNFα与C IV、LN及HA在CAH组患者中呈正相关 (P <0 0 5 ) ,而在LC组患者中无相关性 (P >0 0 5 )。结果提示慢性肝病患者血清TNFα水平增高是肝纤维化活动期的一种重要指标。In order to investigate the relation of type IV collagen(C-IV), laminin(LN) and hyaluronic acid(HA) with tumor necrosis factor α (TNFα) in the sera of patients with chronic liver disease, serum C-IV,LN, HA and TNFα levels were measured by radioimmunoassay in 85 patients with chronic persistent hepatitis(CPH), chronic active hepatitis(CAH) and cirrhosis of liver(LC). The results showed that , compared with 30 healthy control subjects , serum C-IV and HA levels were significantly(P<0.01) elevated in patients with liver disease , while LN levels was significantly(P<0.01) increaed in patients with CAH and LC. Moreover , C-IV , LN and HA levels were increasing progressively with the degree of hepatic fibrosis . Serum TNFα level was also increased in patients with CAH and LC, which was higher in CAH than in LC. In addition, TNFα was found positively correlated with C-IV ,LN and HA serum levels in patients with CAH(P<0.05), while no significant assocaition was seen with LC patients (P<0.05). These findings strongly suggested that increased serum TNFα level could be used as a important marker of active hepatic fibrosis.

关 键 词：层粘蛋白 透明质酸 肝纤维化 慢性肝炎 Ⅳ型胶原 

分 类 号：R512.602[医药卫生—内科学] R575.202[医药卫生—临床医学]