27例无症状神经梅毒病例分析  

Analysis on 27 cases with asymptomatic neurosyphilis

作　　者：荣在丽[1] 魏春波[2] 伦文辉[2] 徐克沂[2] 

机构地区：[1]航空总医院皮肤科,北京100012 [2]首都医科大学附属地坛医院,北京100005

出　　处：《中国医药科学》2013年第20期162-163,共2页China Medicine And Pharmacy

摘　　要：目的了解无症状神经梅毒的临床及实验室特征，以减少临床中的误诊误治。方法对2008年8月～2011年8月收治的27例无症状神经梅毒从年龄、性别、实验室、治疗、转归方面进行回顾性分析。结果27例无症状神经梅毒患者，血清RPR滴度从1：8到1：128不等。合并HIV感染的6例患者中，CD4细胞计数小于350个／μL者4例。在脑脊液检测中22例出现白细胞升高（81．5％），6例出现脑脊液蛋白升高（22．2％），9例出现颅压升高（33．3％）。结论在临床工作中，及时发现无症状神经梅毒，特别是HIV感染人群，及时治疗可以有效减少性症状性神经梅毒的发生。Objective To understand the clinical and laboratory features of asymptomatic neurosyphilis in order to reduce the clinical misdiagnosis and mistreatment. Methods The age, sex, laboratory, treatment and prognosis of 27 cases with asymptomatic neurosyphilis selected from August 2008 to August 2011 were retrospectively analyzed. Results In 27 cases with asymptomatic neurosyphilis, serum RPR titers ranged from ! ： 8 to I ： 128. In 6 cases complicated with HIV infection, the CD4 cell counts of 4 cases was less than 350 cells / μL. In the detection of cerebrospinal fluid, 22 cases（81.5%） were complicated with leukocytosis, 6 cases（22.2%） were complicated with elevated cerebrospinal fluid protein concentration, and 9 cases（33.3%） were complicated with increased intracranial pressure. Conclusion In clinical work, discover and therapy asymptomatic neurosyphilis in time, especially in HIV infected patients, can effectively reduce the incidence of symptomatic neurosyphilis.

关 键 词：无症状神经梅毒 临床及实验室特征 HIV感染 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]