5539例孕妇孕中期唐氏筛查结果分析  

Analysis on results of prenatal screening for Down' syndrome in the second trimester of pregnancy in 5539 cases

作　　者：柴晓静[1] 朱江[1] 张萍[2] 李娟[1] 陆莉[1] 赵丽[1] 

机构地区：[1]兰州大学第一医院中心实验室,兰州730000 [2]兰州大学第一医院妇产科,兰州730000

出　　处：《重庆医科大学学报》2013年第10期1177-1179,共3页Journal of Chongqing Medical University

摘　　要：目的:分析兰州大学第一医院2009年到2012年5 539例孕妇孕中期唐氏筛查结果,试图找出高危孕妇的可能危险因素。方法:采用时间分辨法检测孕妇外周血中游离β绒毛膜促性腺激素和甲胎蛋白的浓度,配合孕妇的年龄、孕周、体质量等,应用专用软件计算出该孕妇的唐氏风险率。结果:筛查出唐氏高风险的孕妇238例,占4.30%;≥35岁组的筛出率最高,为17.69%。结论:扩大唐氏筛查的筛查范围,再配合产前诊断是减少唐氏儿出生的最有效手段。Objective：To analyze results of prenatal screening for Down＇ syndrome in the second trimester of pregnancy in 5 539 cases in the First Hospital of Lanzhou University from 2009 to 2012 and to identify the possible risk factors for high risk pregnant women. Methods：Serum alpha-fetoprotein and free-~ human chorionic gonadotropin in pregnant women were detected based on the principalof time-resolved immunoflourometric assay. Risk of fetal Down＇ syndrome was calculated by computer software taking into con- siderations of maternal age, gestational age, weight of pregnant women. Results：Among the 5 539 pregnant women,238 eases（4.30%） were at high risk for Down＇ syndrome. Sieving rate of those above 35-year-old was the highest（17.69%）. Conclusions：Ex- panding the range of Down＇ syndrome screening of those combination of prenatal diagnosis is effective in reducing Down＇ s children.

关 键 词：唐氏筛查 高危分析 

分 类 号：R175.5[医药卫生—妇幼卫生保健]