异丙酚氯胺酮混合液静脉麻醉  

A Combined Use of Propofol and Ketamine in Intravenous Anesthesia

作　　者：朋立超 蒋克泉 肖常思[2] 

机构地区：[1]上海市第五人民医院麻醉科,200240 [2]上海医科大学中山医院

出　　处：《皖南医学院学报》2000年第4期335-336,共2页Journal of Wannan Medical College

摘　　要：选择 40例 ASA ～ 级病人行异丙酚氯胺酮 (1∶ 2 )复合静脉麻醉。结果麻醉诱导后血压、心率与麻醉前相比无明显变化 ,2 0 %病人出现一过性 SPO2 下降 (<94% )。麻醉诱导苏醒快 ,满意率高 ,恢复期无精神症状。表明异丙酚可控制氯胺酮的心血管兴奋作用和恢复期精神症状 ,氯胺酮可减轻异丙酚的心血管抑制作用。两者配伍是一种较好的短效静脉麻醉方式 ,但仍存在呼吸抑制作用 ,应引起注意。Forty patients with ASA Ⅰ～Ⅱ were selected for intravenous anesthesia with propofol mixed with ketamine in a proportion of 1 to 2, with no remarkable difference found either in blood pressure or in heart rate in comparison with the pre anesthetic state, though a transient SPO\-2 decrease(less than 94%) occurred in 20% of them . A quick and satisfactory palinesthesia was seen in the present anesthesia induction without any marked mental symptom in the recovery phase. All these findings indicate that propofol might be excitoinhibitory againt ketamine which might in turn be capable of relieving the cardiovascular inhibitory action induced by propofol. The combined use of both substances, though a good intravenous anesthetic choice of short action,should be cautiously administered due to its inhibitory effect on respiration.

关 键 词：异丙酚 氯胺酮 静脉内麻醉 混合液 

分 类 号：R614.24[医药卫生—麻醉学] R971.2[医药卫生—外科学]