血氧饱和度与急性高原病关系的Meta分析  

Meta-analysis of the relationship of arterial oxygen saturation and acute mountain sickness

作　　者：游海燕[1] 李潇潇[1] 黄朝晖[1] 高钰琪[2] 

机构地区：[1]第三军医大学卫勤训练基地卫生勤务学教研室,重庆400038 [2]第三军医大学高原医学教育部重点实验室全军高原医学重点实验室,重庆400038

出　　处：《解放军医学杂志》2013年第11期940-943,共4页Medical Journal of Chinese People's Liberation Army

基　　金：国家科技支撑计划项目(2009BAI85B01)~~

摘　　要：目的探讨大规模人群急进高原时易感危险因素动脉血氧饱和度（SaO2）与急性高原病（AMS）的关系。方法计算机检索Medline、PubMed、Springer、Elsevier、Lww等全文文献数据库，收集国外2000年-2010年公开发表的关于人群AMS与易感因子SaO2关系的研究文献，采用RevMan5．0软件对纳入的研究进行Meta分析。结果共纳人9篇关于人群AMS与危险因素SaO2关系的研究文献。异质性检验表明9篇文章的研究属于同一性质（Q=12．98．df=10，P〉0．05），可采用固定效应模型进行合并。合并后累计AMS症状组246例，非AMs症状组557例。采用固定效应模型测试总体效应，结果表明AMS组SaO2值显著低于非AMS组（WMD=4．04，95％CI3．36～4．71，P〈0．00001），提示SaO2是有统计学意义的AMS易感危险因子。结论健康人员快速进入高海拔地区时，SaO2与AMS的发生具有密切关系，监测急进高原人群SaO，的变化有利于及时采取相应的保障措施。Objective To explore the relationship between the arterial oxygen saturation （SaO2） as a susceptibility risk factor for acute mountain sickness （AMS） in healthy people entering a high altitude area abruptly. Methods A search in Medline, PubMed, Springer, Elsevier and LWW databases was done to collect the reports concerning SaO2 as a susceptibility risk factor for AMS from 2000 to 2010 published in literature abroad, and meta-analysis was performed with RevMan 5.0 software. Results Nine papers concerning the relationship of AMS and SaO2 were retrieved. The heterogeneity test indicated that the nine studies were consistent statistically （Q=12.98, df=10, P〉0.0S）, the data from these nine studies could be analyzed by fixed effect model. After combination of the data, those of 246 subjects with AMS and 557 subjects without AMS were collected. Test of overall effect by fixed effect model showed that the SaO2 was significantly lower in AMS group than in non-AMS group （weighted mean difference was 4.04, 95%CI was 3.36-4.71, P〈0.00001）, implying that SaO2 was a susceptibility risk factor for AMS with statistical significance. Conclusions SaO2 was found to be closely associated with AMS when healthy people entering a high altitude area abruptly, and monitoring the changes of SaO2 may be profitable in taking effective measures for prophylaxis and treatment of AMS.

关 键 词：高原病 危险因素 血氧饱和度 META分析 

分 类 号：R821.4[医药卫生—临床医学]