何氏加味定喘汤对慢性支气管炎大鼠内皮素-1及肺组织形态学的影响  

Effect of Modified Dingchuan Decoction(何氏加味定喘汤) on ET-1 and Histomorphology of Rats with Chronic Bronchitis

作　　者：周运海[1] 杨洋[1] 

机构地区：[1]苏州市中医医院,江苏苏州215000

出　　处：《吉林中医药》2013年第10期1038-1040,1045,共4页Jilin Journal of Chinese Medicine

摘　　要：目的观察何氏加味定喘汤对慢性支气管炎模型大鼠血清、肺组织匀浆中ET-1及肺、支气管组织病理形态的影响。方法慢性支气管炎大鼠模型随机分为:模型对照组、止嗽合剂组、何氏加味定喘汤组(高、中低剂量)。灌胃给药20 d。监测大鼠血清、肺组织匀浆中ET-1含量,观察肺及支气管组织病理切片。结果模型组大鼠血清、肺组织中ET-1明显升高(P<0.05)。何氏加味定喘汤3个剂量组及阳性对照组血清中ET-1明显降低(P<0.05或P<0.01),正常对照组无明显病理形态学改变,模型组病理损害显著。结论何氏加味定喘汤可降低慢性支气管炎大鼠ET-1的含量,改善支气管、肺组织损伤程度。Objective To observe the effect of Modified Dingchuan Decoction on serum, lung tissue of rats with chronic bronchitis lung homogenate ET-1, bronchial tissue. Methods The rat model of chronic bronchitis, were randomly divided into three groups： model control group, Zhisou Decoction group, Modified Dingchuan Decoction group （high, middle, low dose）. Intragastric administration 20 d. Monitor the content of ET-1 in serum, lung tissue homogenate of rats, observe the lung and bronchial tissue pathological slices. Results the serum ET- 1, lung tissue of the rats in the model group increased significantly（ P 〈 0.05）.ET-1 in 3 ~9-oup of Modified Dingchuan Decoction and positive control group were decreased signif- icantly（ P 〈 0.05 or P 〈 0.01 ）, the normal control group had no obvious pathological change, and the model group pathological damage significantly. Conclusion Modified Dingchuan Decoction could reduce the content of ET-1 in rats with chronic bronchitis and improve the bronchial and lung tissue injury.

关 键 词：何氏加味定喘汤 慢性支气管炎 ET-1 病理改变 大鼠 

分 类 号：R285.5[医药卫生—中药学]