葡猕汤对高脂血症大鼠血脂的影响  

Effect of Pumi Decoction(葡猕汤)on Serum Lipid in Hyperlipoidemia Rats

作　　者：万安霞[1,2] 俞昌琪[3] 

机构地区：[1]湖北中医药大学,武汉430065 [2]南京信息工程大学,南京210044 [3]贵阳中医学院,贵阳550002

出　　处：《吉林中医药》2013年第10期1041-1042,共2页Jilin Journal of Chinese Medicine

基　　金：贵州省中药管理局资助项目(2007)

摘　　要：目的观察高脂血症大鼠用葡猕汤治疗前后血清中TC、TG的水平,初探葡猕汤调节血脂的情况方法将55只雄性Wistar大鼠随机分为空白组、模型组、葡猕汤组〔8 g/(kg·d)〕、复方葡猕汤组〔11 g/(kg·d)〕和辛伐他汀组〔1 mg/(kg·d)〕,共5组,每组11只,观察6周。脂肪乳剂灌胃〔10 mL/(kg·d)〕,2周及药物治疗4周后分别检测大鼠血清中TC、TG的含量。结果模型复制成功,葡猕汤组的TC、TG水平较模型组明显降低(P<0.05)。结论葡猕汤明显降低血脂,有调节高脂血症作用。Objective To evaluate the changes of total cholesterol（TC） and triglyceride（TG） before and after treatment with Pumi decoction and study the mechanism of Pumi decoction treating hyperlipoidemia. Methods 55 male Wistar rats were randomly divided into control group, hyperlipoidemia group, Pumi decoction group （ 8 g/kg. d）, compound Pumi decoction group（ 11 g/kg＇d）and Western medicine group （ 1 mg/kg.d）.A total of 5 groups with 11 in each group were observed for 6 weeks. High-fat emulsion administered 2 weeks and drug treatment for 4 weeks. The levels of TC and TG in serum were mea- sured. Results Hyperlipoidemia model was successful. The TC, TG level was markedly decreased as compared with those in hyperlipoidemia group （ P 〈 0.05）. Conclusion Pumi decoction group could effectively decrease lipid and may play a role in the treatment of hyperlipoidemia.

关 键 词：葡猕汤 高脂血症 清热解毒 活血化瘀 野葡萄根 猕猴桃根 大鼠 

分 类 号：R285.5[医药卫生—中药学]