维生素D3对2型糖尿病患者血管内皮功能的保护作用  

The protective effect of vitamin D3 on vascular endothelial function in patients with type 2 diabetes mellitus

作　　者：朱广平[1] 

机构地区：[1]广州军区武汉总医院内分泌科,武汉430070

出　　处：《临床内科杂志》2013年第10期692-694,共3页Journal of Clinical Internal Medicine

摘　　要：目的 探讨1,25-二羟维生素D3对2型糖尿病患者血管内皮功能的影响.方法 选取我科2009～2011年住院的2型糖尿病患者80例,随机分为治疗组和对照组各40例,在血糖稳定1周后,治疗组给予常规治疗＋骨化三醇胶丸,对照组给予常规治疗,两组患者疗程均为12周.治疗前后行内皮依赖性血管舒张功能检测,同时检测其血C反应蛋白（CRP）、白细胞介素（IL）-6水平.结果 经过12周的治疗,治疗组患者体内CRP、IL-6低于对照组（P均＜0.05）；且治疗组患者内皮依赖性血管内径变化率高于对照组（P＜0.05）.结论 维生素D3可显著改善2型糖尿病患者体内的炎症状态,并改善2型糖尿病患者血管内皮功能.Objective To explore the effect of vitamin D3 on vascular endothelial function in patients with type 2 diabetes mellitus（T2DM）.Methods 80 patients with type 2 diabetes mellitus in our hospital from 2009 to 2011 were chosen,and were randomly divided into the control and vitamin D groups.Patients of both groups were treated with basic medicine to control the blood glucose level and the patients in vitamin D3 group were orally administered vitamin D3 1000 IU daily in addition.C-reactive protein （CRP）,interleukin-6 （IL-6）,fast plasma glucose （FPG） were detected before and after the 12-week intervention.At the same time,the endothelium-dependent vascular relaxing function were detected by ultrasound.Results After 12 weeks of treatment,the level of CRP,IL-6 in the vitamin D3 group were significantly lower than that in the control group （all P ＜ 0.05）,and the endothelium-dependent vasodilation rate of the patients in the vitamin D3 group was higher than that in the control group（all P ＜ 0.05）.Conclusion Vitamin D3 supplementation for 12 weeks has improved inflammation and vascular endothelial function significantly in T2DM.

关 键 词：维生素D3 血管内皮功能 2型糖尿病 炎症因子 

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